Literature DB >> 15242255

Epothilone D (Kosan/Roche).

Ada Kolman1.   

Abstract

Kosan and Roche are developing the microtubule inhibitor epothilone D (KOS-862 and NSC-703147), an analog of epothilone B for the potential treatment of cancer. Phase II trials in colorectal, metastatic breast and non-small-cell lung cancers were initiated in December 2003.

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Year:  2004        PMID： 15242255

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  10 in total

1.  Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Authors:  Donna M Barten; Patrizia Fanara; Cathy Andorfer; Nina Hoque; P Y Anne Wong; Kristofor H Husted; Gregory W Cadelina; Lynn B Decarr; Ling Yang; Victoria Liu; Chancy Fessler; Joan Protassio; Timothy Riff; Holly Turner; Christopher G Janus; Sethu Sankaranarayanan; Craig Polson; Jere E Meredith; Gemma Gray; Amanda Hanna; Richard E Olson; Soong-Hoon Kim; Gregory D Vite; Francis Y Lee; Charles F Albright
Journal:  J Neurosci       Date:  2012-05-23       Impact factor: 6.167

Review 2.  Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.

Authors:  K C Nicolaou; Christopher R H Hale; Christian Nilewski; Heraklidia A Ioannidou
Journal:  Chem Soc Rev       Date:  2012-06-28       Impact factor: 54.564

Review 3.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

Review 4.  Microtubule-binding agents: a dynamic field of cancer therapeutics.

Authors:  Charles Dumontet; Mary Ann Jordan
Journal:  Nat Rev Drug Discov       Date:  2010-10       Impact factor: 84.694

Review 5.  Targeting microtubules by natural agents for cancer therapy.

Authors:  Eiman Mukhtar; Vaqar Mustafa Adhami; Hasan Mukhtar
Journal:  Mol Cancer Ther       Date:  2014-01-16       Impact factor: 6.261

6.  Notch signalling in adult neurons: a potential target for microtubule stabilization.

Authors:  Sara Anna Bonini; Giulia Ferrari-Toninelli; Mery Montinaro; Maurizio Memo
Journal:  Ther Adv Neurol Disord       Date:  2013-11       Impact factor: 6.570

Review 7.  Of microtubules and memory: implications for microtubule dynamics in dendrites and spines.

Authors:  Erik W Dent
Journal:  Mol Biol Cell       Date:  2017-01-01       Impact factor: 4.138

Review 8.  Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.

Authors:  Sara Anna Bonini; Andrea Mastinu; Giulia Ferrari-Toninelli; Maurizio Memo
Journal:  Int J Mol Sci       Date:  2017-07-26       Impact factor: 5.923

9.  Efficacy of epothilones in central nervous system trauma treatment: what has age got to do with it?

Authors:  Jayden Clark; Zhendan Zhu; Jyoti Chuckowree; Tracey Dickson; Catherine Blizzard
Journal:  Neural Regen Res       Date:  2021-04       Impact factor: 5.135

Review 10.  Microtubules as Regulators of Neural Network Shape and Function: Focus on Excitability, Plasticity and Memory.

Authors:  Fernando Peña-Ortega; Ángel Abdiel Robles-Gómez; Lorena Xolalpa-Cueva
Journal:  Cells       Date:  2022-03-08       Impact factor: 6.600
  10 in total

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