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Literature DB >> 15240393

Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression.

R Hashimoto¹, T Nagatsu, T Ohta, M Mizutani, I Omura.

Abstract

This paper studies changes in the concentrations of tetrahydrobiopterin (BH4), the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression. BH4 was found to be transiently released from the sympathetic nerves under severe physical stress but continuously released in depression with an increased oxidation rate of BH4 to B.

Entities: Chemical Disease

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Year: 2004 PMID： 15240393 DOI： 10.1196/annals.1296.047

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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Cited

11 in total

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Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression.

1. Tyrosine metabolism during interferon-alpha administration: association with fatigue and CSF dopamine concentrations.

Review 2. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise.

Review 3. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.

4. Purification, crystallization and preliminary X-ray diffraction studies of UDP-glucose:tetrahydrobiopterin α-glucosyltransferase (BGluT) from Synechococcus sp. PCC 7942.

Review 5. The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies.

6. The effects of different aerobic exercise intensities on serum serotonin concentrations and their association with Stroop task performance: a randomized controlled trial.

Review 7. Inflammation Effects on Motivation and Motor Activity: Role of Dopamine.

8. Pterins as sensors of response to the application of Fe3+ -dextran in piglets.

9. Pteridine glycosyltransferase from Chlorobium tepidum: crystallization and X-ray analysis.

Review 10. Imaging the Role of Inflammation in Mood and Anxiety-related Disorders.