Literature DB >> 15239852

Retrospective detection of exposure to sulfur mustard: improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin-sulfur mustard adducts.

D Noort1, A Fidder, A G Hulst, A R Woolfitt, D Ash, J R Barr.   

Abstract

We here report on the further development of the method comprising the pronase digestion of albumin alkylated by sulfur mustard and the subsequent mass spectrometric analysis of an adducted tripeptide. This includes significant improvements in both the albumin isolation procedure and the automation of the microliquid chromatography-electrospray-tandem mass spectrometric analysis. We also report on the results of a small reference range study, in which we have established that there are no detectable interferences in sera from unexposed individuals.

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Year:  2004        PMID： 15239852     DOI： 10.1093/jat/28.5.333

Source DB:  PubMed          Journal:  J Anal Toxicol        ISSN： 0146-4760            Impact factor:   3.367


  6 in total

Review 1.  Modern instrumental methods in forensic toxicology.

Authors:  Michael L Smith; Shawn P Vorce; Justin M Holler; Eric Shimomura; Joe Magluilo; Aaron J Jacobs; Marilyn A Huestis
Journal:  J Anal Toxicol       Date:  2007-06       Impact factor: 3.367

2.  An enhanced throughput method for quantification of sulfur mustard adducts to human serum albumin via isotope dilution tandem mass spectrometry.

Authors:  Tracy M Andacht; Brooke G Pantazides; Brian S Crow; Alex Fidder; Daan Noort; Jerry D Thomas; Thomas A Blake; Rudolph C Johnson
Journal:  J Anal Toxicol       Date:  2013-11-07       Impact factor: 3.367

3.  Simplified Method for Quantifying Sulfur Mustard Adducts to Blood Proteins by Ultrahigh Pressure Liquid Chromatography−Isotope Dilution Tandem Mass Spectrometry.

Authors:  Brooke G Pantazides; Brian S Crow; Joshua W Garton; Jennifer A Quiñones-González; Thomas A Blake; Jerry D Thomas; Rudolph C Johnson
Journal:  Chem Res Toxicol       Date:  2015-02-16       Impact factor: 3.739

4.  A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts.

Authors:  Brooke G Pantazides; Jennifer Quiñones-González; Danisha M Rivera Nazario; Brian S Crow; Jonas W Perez; Thomas A Blake; Rudolph C Johnson
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2019-05-05       Impact factor: 3.205

5.  2-Amino-9H-pyrido[2,3-b]indole (AαC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke.

Authors:  Khyatiben V Pathak; Medjda Bellamri; Yi Wang; Sophie Langouët; Robert J Turesky
Journal:  J Biol Chem       Date:  2015-05-07       Impact factor: 5.157

6.  A proteomics strategy for the identification of multiple sites in sulfur mustard-modified HSA and screening potential biomarkers for retrospective analysis of exposed human plasma.

Authors:  Bo Chen; Qiaoli Zhang; Zhe Ren; Tao Zhang; Huilan Yu; Changcai Liu; Yang Yang; Ping Xu; Shilei Liu
Journal:  Anal Bioanal Chem       Date:  2022-04-27       Impact factor: 4.142
  6 in total

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