Literature DB >> 15239291

Understanding cystic-fibrosis-related diabetes: best thought of as insulin deficiency?

Lee Dobson1, Christopher D Sheldon, Andrew T Hattersley.   

Abstract

The limited available evidence supports the use of insulin treatment in CFRD. This fits with the dominant problem in CFRD being insulin deficiency and progressive beta cell dysfunction, making tablets that stimulate the beta cell unlikely to be a successful strategy. It is possible that patients with IGT or CFRD with moderate hyperglycaemia (e.g. relative preservation of fasting glucose) may initially respond to beta cell secretagogues. A large randomized prospective trial in the USA should answer this point in the next few years.

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Year:  2004        PMID： 15239291      PMCID： PMC1308796     

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   5.344


  67 in total

1.  Endogenous and exogenous insulin responses in patients with cystic fibrosis.

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Journal:  Pediatrics       Date:  1975-01       Impact factor: 7.124

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Journal:  Arch Dis Child       Date:  1989-05       Impact factor: 3.791

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Authors:  A Moran; K L Pyzdrowski; J Weinreb; B B Kahn; S A Smith; K S Adams; E R Seaquist
Journal:  Diabetes       Date:  1994-08       Impact factor: 9.461

4.  Identification and treatment of cystic fibrosis-related diabetes. A survey of current medical practice in the U.S.

Authors:  H F Allen; E C Gay; G J Klingensmith; R F Hamman
Journal:  Diabetes Care       Date:  1998-06       Impact factor: 19.112

5.  Glycosylated haemoglobin and glucose intolerance in cystic fibrosis.

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Journal:  Arch Dis Child       Date:  1987-08       Impact factor: 3.791

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Journal:  Science       Date:  1989-09-08       Impact factor: 47.728

7.  Cystic fibrosis associated islet changes may provide a basis for diabetes. An immunocytochemical and morphometrical study.

Authors:  M Löhr; P Goertchen; H Nizze; N S Gould; V E Gould; M Oberholzer; P U Heitz; G Klöppel
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989

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Authors:  A O Redmond; K D Buchanan; E R Trimble
Journal:  Acta Paediatr Scand       Date:  1977-03

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Authors:  F W Abdul-Karim; B B Dahms; M E Velasco; H M Rodman
Journal:  Arch Pathol Lab Med       Date:  1986-07       Impact factor: 5.534

Review 10.  Diabetes in cystic fibrosis.

Authors:  B Yung; M E Hodson
Journal:  J R Soc Med       Date:  1999       Impact factor: 18.000
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  4 in total

Review 1.  Cystic fibrosis-related diabetes in children--gaps in the evidence?

Authors:  Malay Rana; Craig F Munns; Hiran Selvadurai; Kim C Donaghue; Maria E Craig
Journal:  Nat Rev Endocrinol       Date:  2010-05-25       Impact factor: 43.330

2.  Early glucose abnormalities in cystic fibrosis are preceded by poor weight gain.

Authors:  Shihab Hameed; John R Morton; Adam Jaffé; Penny I Field; Yvonne Belessis; Terence Yoong; Tamarah Katz; Charles F Verge
Journal:  Diabetes Care       Date:  2009-11-12       Impact factor: 19.112

3.  CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.

Authors:  Anna Edlund; Jonathan L S Esguerra; Anna Wendt; Malin Flodström-Tullberg; Lena Eliasson
Journal:  BMC Med       Date:  2014-05-28       Impact factor: 8.775

4.  The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.

Authors:  Ghislaine Fontés; Julien Ghislain; Isma Benterki; Bader Zarrouki; Dominique Trudel; Yves Berthiaume; Vincent Poitout
Journal:  Diabetes       Date:  2015-08-17       Impact factor: 9.461
  4 in total

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