Literature DB >> 15237100

Pharmacological prevention of cardiovascular aging--targeting the Maillard reaction.

Doron Aronson1.   

Abstract

The development of myocardial and large vessel stiffness with aging underlies the development of diastolic heart failure and isolated systolic hypertension. Nonenzymatic reaction between glucose and proteins (Maillard reaction) leading to collagen crosslinking in the myocardium and arterial wall has been implicated in age-related increase in cardiovascular stiffness. In the present issue, Chang et al. show that aminoguanidine, an inhibitor of protein crosslinking, retards age-related decline in the elastic properties of the left ventricle and arteries. The significance of these findings is discussed in this commentary. Copyright 2004 Nature Publishing Group

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Year:  2004        PMID： 15237100      PMCID： PMC1575180          DOI： 10.1038/sj.bjp.0705832

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  29 in total

1.  An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.

Authors:  M Asif; J Egan; S Vasan; G N Jyothirmayi; M R Masurekar; S Lopez; C Williams; R L Torres; D Wagle; P Ulrich; A Cerami; M Brines; T J Regan
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

2.  Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy.

Authors:  P Poirier; P Bogaty; C Garneau; L Marois; J G Dumesnil
Journal:  Diabetes Care       Date:  2001-01       Impact factor: 19.112

3.  Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.

Authors:  D A Kass; E P Shapiro; M Kawaguchi; A R Capriotti; A Scuteri; R C deGroof; E G Lakatta
Journal:  Circulation       Date:  2001-09-25       Impact factor: 29.690

Review 4.  The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.

Authors:  A M Schmidt; S D Yan; S F Yan; D M Stern
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

5.  A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.

Authors:  P V Vaitkevicius; M Lane; H Spurgeon; D K Ingram; G S Roth; J J Egan; S Vasan; D R Wagle; P Ulrich; M Brines; J P Wuerth; A Cerami; E G Lakatta
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

Review 6.  Protein glycation, diabetes, and aging.

Authors:  P Ulrich; A Cerami
Journal:  Recent Prog Horm Res       Date:  2001

7.  Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).

Authors:  B I Freedman; J P Wuerth; K Cartwright; R P Bain; S Dippe; K Hershon; A D Mooradian; B S Spinowitz
Journal:  Control Clin Trials       Date:  1999-10

Review 8.  Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes.

Authors:  Doron Aronson
Journal:  J Hypertens       Date:  2003-01       Impact factor: 4.844

9.  Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study.

Authors:  Agha W Haider; Martin G Larson; Stanley S Franklin; Daniel Levy
Journal:  Ann Intern Med       Date:  2003-01-07       Impact factor: 25.391

10.  Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes.

Authors:  Ralica Petrova; Yasuhiko Yamamoto; Katsuhiko Muraki; Hideto Yonekura; Shigeru Sakurai; Takuo Watanabe; Hui Li; Masayoshi Takeuchi; Zenji Makita; Ichiro Kato; Shin Takasawa; Hiroshi Okamoto; Yuji Imaizumi; Hiroshi Yamamoto
Journal:  J Mol Cell Cardiol       Date:  2002-10       Impact factor: 5.000
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  3 in total

Review 1.  Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart.

Authors:  Jia Zhao; Rushil Randive; James A Stewart
Journal:  World J Diabetes       Date:  2014-12-15

2.  Effect of lysyl oxidase inhibition on angiotensin II-induced arterial hypertension, remodeling, and stiffness.

Authors:  Lance S Eberson; Pablo A Sanchez; Beenish A Majeed; Supannikar Tawinwung; Timothy W Secomb; Douglas F Larson
Journal:  PLoS One       Date:  2015-04-13       Impact factor: 3.240

3.  A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.

Authors:  Takahiro Kochi; Masahito Shimizu; Yukari Totsuka; Yohei Shirakami; Takayuki Nakanishi; Tetsushi Watanabe; Takuji Tanaka; Hitoshi Nakagama; Keiji Wakabayashi; Hisataka Moriwaki
Journal:  Toxicol Rep       Date:  2014-04-30
  3 in total

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