| Literature DB >> 15236838 |
Ram Shankar Upadhayaya1, Sanjay Jain, Neelima Sinha, Nawal Kishore, Ramesh Chandra, Sudershan K Arora.
Abstract
In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal activity against Candida spp., Cryptococcus neoformans, and Aspergillus spp. in vitro. The location of the methyl group at the C-3 of compounds 12 and 14 has been demonstrated to be a key structural element of antifungal potency.Entities:
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Year: 2004 PMID： 15236838 DOI： 10.1016/j.ejmech.2004.03.004
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514