Radioallergosorbent test (RAST) for specific IgE antibody to lidocaine, procaine and methylparaben.

Although anaphylactoid reactions to local anesthetics are well known, a radioallergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acid derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who were regarded to be nonallergic to the drugs used. Negative RAST values obtained from these volunteers were 1653 +/- 254(SD) cpm (lidocaine), 2750 +/- 264 cpm (procaine), and 2805 +/- 336 cpm (methyl paraben).