Literature DB >> 15235984

Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam.

H Horikawa1, T Tada, M Sakai, T Karube, K Ichiyanagi.   

Abstract

The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.

Entities:  

Year:  1990        PMID： 15235984     DOI： 10.1007/s0054000040265

Source DB:  PubMed          Journal:  J Anesth        ISSN： 0913-8668            Impact factor:   2.078


  9 in total

1.  ANTICONVULSANT PROPERTIES OF SOME BENZODIAZEPINE DERIVATIVES. POSSIBLE USE AGAINST PSYCHOMOTOR SEIZURES.

Authors:  E EIDELBERG; H M NEER; M K MILLER
Journal:  Neurology       Date:  1965-03       Impact factor: 9.910

2.  Diazepam blocks cerebral metabolic and circulatory responses to local anesthetic-induced seizures.

Authors:  T Maekawa; T Sakabe; H Takeshita
Journal:  Anesthesiology       Date:  1974-10       Impact factor: 7.892

3.  The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram.

Authors:  T Sakabe; T Maekawa; T Ishikawa; H Takeshita
Journal:  Anesthesiology       Date:  1974-05       Impact factor: 7.892

4.  Site of action of diazepam in the prevention of lidocaine induced seizure activity in cats.

Authors:  N Wale; L C Jenkins
Journal:  Can Anaesth Soc J       Date:  1973-03

5.  Simultaneous cerebral blood flow measured by direct and indirect methods.

Authors:  J D Michenfelder; J M Messick; R A Theye
Journal:  J Surg Res       Date:  1968-10       Impact factor: 2.192

6.  Selective metabolic activation of the hippocampus during lidocaine-induced pre-seizure activity.

Authors:  M Ingvar; H M Shapiro
Journal:  Anesthesiology       Date:  1981-01       Impact factor: 7.892

7.  The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats.

Authors:  N Seo; E Oshima; J Stevens; K Mori
Journal:  Anesthesiology       Date:  1982-12       Impact factor: 7.892

8.  Local cerebral blood flow during lidocaine-induced seizures in rats.

Authors:  C Tommasino; T Maekawa; H M Shapiro
Journal:  Anesthesiology       Date:  1986-06       Impact factor: 7.892

9.  The influence of droperidol, diazepam, and physostigmine on ketamine-induced behavior and brain regional glucose utilization in rat.

Authors:  K Oguchi; K Arakawa; S R Nelson; F Samson
Journal:  Anesthesiology       Date:  1982-11       Impact factor: 7.892
  9 in total
  2 in total

1.  Tourniquet Deflation Prior to 20 Minutes in Upper Extremity Intravenous Regional Anesthesia.

Authors:  Richard W Gurich; Justin W Langan; Robert J Teasdall; Stephanie L Tanner; John L Sanders
Journal:  Hand (N Y)       Date:  2017-01-04

Review 2.  First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines.

Authors:  Marios Charalambous; Holger A Volk; Luc Van Ham; Sofie F M Bhatti
Journal:  BMC Vet Res       Date:  2021-03-04       Impact factor: 2.741
  2 in total

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