F W Fraunfelder1, F T Fraunfelder. 1. Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA. eyedrug@ohsu.edu
Abstract
PURPOSE: To report recent ocular adverse drug reactions identified by the National Registry of Drug-Induced Ocular Side Effects. METHODS: Case reports from the National Registry and the World Health Organization were collected and adverse drug reactions categorized as follows: certain, probable/likely, possible, unlikely, and conditional/unclassifiable. RESULTS: Bisphosphonates are associated with ocular inflammation, including the first reports of drug-related scleritis. Topiramate is shown to cause angle-closure glaucoma. Cetirizine can cause an oculogyric crisis, and there is strong evidence retinoids cause intracranial hypertension. CONCLUSION: Recent reports to the National Registry have led to identification of new ocular adverse drug reactions.
PURPOSE: To report recent ocular adverse drug reactions identified by the National Registry of Drug-Induced Ocular Side Effects. METHODS: Case reports from the National Registry and the World Health Organization were collected and adverse drug reactions categorized as follows: certain, probable/likely, possible, unlikely, and conditional/unclassifiable. RESULTS:Bisphosphonates are associated with ocular inflammation, including the first reports of drug-related scleritis. Topiramate is shown to cause angle-closure glaucoma. Cetirizine can cause an oculogyric crisis, and there is strong evidence retinoids cause intracranial hypertension. CONCLUSION: Recent reports to the National Registry have led to identification of new ocular adverse drug reactions.