| Literature DB >> 15234104 |
Guylène Page1, Stéphanie Barc-Pain, Raymond Pontcharraud, Arnaud Cante, Alain Piriou, Laurence Barrier.
Abstract
The neuronal dopamine transporter (DAT) is a presynaptic plasma membrane protein mediating the re-uptake of dopamine released from synaptic cleft into the nerve terminals. While the regulation of its activity by protein kinase C signalling is well-characterized, there is controversial debate about its regulation by protein kinase A (PKA) signalling. In rat striatal synaptosomes, we showed that a cell-permeable cyclic adenosine 3',5'-monophosphate analogue up-regulated the DAT capacity without modification of its efficiency. This acute effect was PKA-, calcium calmodulin dependent kinase II- and phosphatase-dependent. Together, these results suggest that the activity of DAT may depend on a state of the transporter with both specific phosphorylated and dephosphorylated sites.Entities:
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Year: 2004 PMID： 15234104 DOI： 10.1016/j.neuint.2004.04.002
Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921