PURPOSE: The aim of this study was to evaluate whether combination of antioxidants and mesna may prevent cystitis induced by cyclophosphamide better than mesna alone. MATERIALS AND METHODS: A total of 46 male Sprague-Dawley rats were divided into six groups. Five groups received single dose of cyclophosphamide (CP, 100 mg/kg) intraperitoneally with the same time intervals: group 2 received CP only, group 3 received mesna (21.5 mg/kg for three times), group 4 beta-carotene (20 mg/kg for two times) and mesna, group 5 received alpha-tocopherol (20 mg/kg for two times) and mesna, and group 6 received melatonin (5 mg/kg for two times) and mesna on the day of CP injection. Group 1 served as control. RESULTS: CP injection resulted in severe cystitis. Mesna has showed meaningful but not full protection against CP toxicity. Although beta-carotene did not show any additional beneficial effect when combined with mesna, alpha-tocopherol and especially melatonin with mesna resulted full protection that the pathologist, blinded to the slides, could not differ from sham control. CONCLUSION: Oxidants may be important in the pathogenesis of CP-induced cystitis. Melatonin and alpha-tocopherol may help to ameliorate bladder damage along with other drugs such as mesna and diuretics.
PURPOSE: The aim of this study was to evaluate whether combination of antioxidants and mesna may prevent cystitis induced by cyclophosphamide better than mesna alone. MATERIALS AND METHODS: A total of 46 male Sprague-Dawley rats were divided into six groups. Five groups received single dose of cyclophosphamide (CP, 100 mg/kg) intraperitoneally with the same time intervals: group 2 received CP only, group 3 received mesna (21.5 mg/kg for three times), group 4 beta-carotene (20 mg/kg for two times) and mesna, group 5 received alpha-tocopherol (20 mg/kg for two times) and mesna, and group 6 received melatonin (5 mg/kg for two times) and mesna on the day of CP injection. Group 1 served as control. RESULTS: CP injection resulted in severe cystitis. Mesna has showed meaningful but not full protection against CP toxicity. Although beta-carotene did not show any additional beneficial effect when combined with mesna, alpha-tocopherol and especially melatonin with mesna resulted full protection that the pathologist, blinded to the slides, could not differ from sham control. CONCLUSION: Oxidants may be important in the pathogenesis of CP-induced cystitis. Melatonin and alpha-tocopherol may help to ameliorate bladder damage along with other drugs such as mesna and diuretics.
Authors: Ibrahim Keles; Mehmet Fatih Bozkurt; Mustafa Cemek; Mustafa Karalar; Ahmet Hazini; Saadet Alpdagtas; Hikmet Keles; Turan Yildiz; Cavit Ceylan; Mehmet Emin Buyukokuroglu Journal: Int Urol Nephrol Date: 2014-09-24 Impact factor: 2.370
Authors: Evaristus C Mbanefo; Loc Le; Rebecca Zee; Nirad Banskota; Kenji Ishida; Luke F Pennington; Justin I Odegaard; Theodore S Jardetzky; Abdulaziz Alouffi; Franco H Falcone; Michael H Hsieh Journal: Sci Rep Date: 2019-02-07 Impact factor: 4.379
Authors: Ayman M Mousa; Khaled S Allemailem; Fahad A Alhumaydhi; Faris Alrumaihi; Ahmad Almatroudi; Mohammad Aljasir; Ameen S S Alwashmi; Osamah Al Rugaie; Khaled E A Soliman; Abdullah S M Aljohani; Waleed Al Abdulmonem; Ahmed A Ahmed; Arif Khan; Masood A Khan; Naif AlSuhaymi; Mahdi H Alsugoor; Wafa Abdullah Al-Megrin; Abulmaaty M Elsayed Journal: Evid Based Complement Alternat Med Date: 2022-03-17 Impact factor: 2.629