Literature DB >> 15232626

Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.

Yu A Sidorova1, A Yu Grishanova.   

Abstract

We studied the effect of synthetic vitamin K analogue menadione on enzymes of xenobiotic metabolism in rat liver (total content of cytochrome P450 and catalytic activities of CYP1A1/2, CYP2B1, CYP2C, NADPH-cytochrome P450 reductase, and glutathione S-transferase). Menadione induced phase I and II enzymes for metabolism of xenobiotics, drugs, and procarcinogens. The effect of menadione depended on its dose and duration of treatment.

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Year:  2004        PMID： 15232626     DOI： 10.1023/b:bebm.0000031556.47763.04

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  4 in total

1.  Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy.

Authors:  Dean Lim; Robert J Morgan; Steven Akman; Kim Margolin; Brian I Carr; Lucille Leong; Oluwole Odujinrin; James H Doroshow
Journal:  Invest New Drugs       Date:  2005-06       Impact factor: 3.850

2.  Comprehensive evaluation of a novel nuclear factor-kappaB inhibitor, quinoclamine, by transcriptomic analysis.

Authors:  W-Y Cheng; J-C Lien; C-Y Hsiang; S-L Wu; C-C Li; H-Y Lo; J-C Chen; S-Y Chiang; J-A Liang; T-Y Ho
Journal:  Br J Pharmacol       Date:  2009-04-30       Impact factor: 8.739

3.  Menadione Suppresses Benzo(α)pyrene-Induced Activation of Cytochromes P450 1A: Insights into a Possible Molecular Mechanism.

Authors:  Yulia A Sidorova; Maria L Perepechaeva; Elena N Pivovarova; Arkady L Markel; Vyacheslav V Lyakhovich; Alevtina Y Grishanova
Journal:  PLoS One       Date:  2016-05-11       Impact factor: 3.240

4.  Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells.

Authors:  Monivan Chhour; Pierre Perio; Regis Gayon; Hélène Ternet-Fontebasso; Gilles Ferry; Françoise Nepveu; Jean A Boutin; Jan Sudor; Karine Reybier
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810
  4 in total

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