BACKGROUND & OBJECTIVES: The incidence of group A streptococcal (GAS) invasive infections have been increasing worldwide. The aim of this study was to characterize clinical and microbiological features of isolates obtained from invasive GAS infections in North Queensland, Australia between 1996 and 2001. METHODS: Clinical and demographic data were collected prospectively. Isolates were biotyped, emm sequenced, M typed and tested for antibiotic sensitivity using E-test. Detection of the presence of the streptococcal pyrogenic exotoxin (spe) and fibronectin binding protein (prtF1) genes was also carried out. RESULTS: There were 109 isolates from blood and sterile sites. All isolates were sensitive to penicillin. Tetracycline and erythromycin resistance was seen in 11 and 2.7 per cent of isolates respectively. The isolates were evenly distributed by age and sex. The overall mortality was 7 per cent and there were 18 cases of streptococcal toxic shock syndrome (STSS) in which the mortality was 22 per cent. Indigenous patients had a crude incidence rate of 82.5 per 100,000 per year compared with 10.3 per 100,000 per year in the non-indigenous patients. There was no predominance of emm / M type or association of spe type with STSS. There was also no relationship between the presence of the prtF1 gene and invasive disease. INTERPRETATION & CONCLUSION: Invasive group A streptococci from North Queensland are similar to those from the Northern Territory of Australia in that no single strain is predominant. The indigenous population is overrepresented. Invasiveness and the development of streptococcal toxic shock is not related to the presence of the prtF1 gene or spe a or c.
BACKGROUND & OBJECTIVES: The incidence of group A streptococcal (GAS) invasive infections have been increasing worldwide. The aim of this study was to characterize clinical and microbiological features of isolates obtained from invasive GAS infections in North Queensland, Australia between 1996 and 2001. METHODS: Clinical and demographic data were collected prospectively. Isolates were biotyped, emm sequenced, M typed and tested for antibiotic sensitivity using E-test. Detection of the presence of the streptococcal pyrogenic exotoxin (spe) and fibronectin binding protein (prtF1) genes was also carried out. RESULTS: There were 109 isolates from blood and sterile sites. All isolates were sensitive to penicillin. Tetracycline and erythromycin resistance was seen in 11 and 2.7 per cent of isolates respectively. The isolates were evenly distributed by age and sex. The overall mortality was 7 per cent and there were 18 cases of streptococcal toxic shock syndrome (STSS) in which the mortality was 22 per cent. Indigenous patients had a crude incidence rate of 82.5 per 100,000 per year compared with 10.3 per 100,000 per year in the non-indigenous patients. There was no predominance of emm / M type or association of spe type with STSS. There was also no relationship between the presence of the prtF1 gene and invasive disease. INTERPRETATION & CONCLUSION: Invasive group A streptococci from North Queensland are similar to those from the Northern Territory of Australia in that no single strain is predominant. The indigenous population is overrepresented. Invasiveness and the development of streptococcal toxic shock is not related to the presence of the prtF1 gene or spe a or c.
Authors: George E Nelson; Tracy Pondo; Karrie-Ann Toews; Monica M Farley; Mary Lou Lindegren; Ruth Lynfield; Deborah Aragon; Shelley M Zansky; James P Watt; Paul R Cieslak; Kathy Angeles; Lee H Harrison; Susan Petit; Bernard Beall; Chris A Van Beneden Journal: Clin Infect Dis Date: 2016-04-22 Impact factor: 9.079
Authors: S Le Hello; A Doloy; F Baumann; N Roques; P Coudene; B Rouchon; F Lacassin; A Bouvet Journal: J Clin Microbiol Date: 2009-12-02 Impact factor: 5.948
Authors: A C Steer; A J W Jenney; F Oppedisano; M R Batzloff; J Hartas; J Passmore; F M Russell; J H H Kado; J R Carapetis Journal: Epidemiol Infect Date: 2007-07-16 Impact factor: 2.451
Authors: Mark J Walker; Timothy C Barnett; Jason D McArthur; Jason N Cole; Christine M Gillen; Anna Henningham; K S Sriprakash; Martina L Sanderson-Smith; Victor Nizet Journal: Clin Microbiol Rev Date: 2014-04 Impact factor: 26.132
Authors: Manisha Pandey; Victoria Ozberk; Ainslie Calcutt; Emma Langshaw; Jessica Powell; Tania Rivera-Hernandez; Mei-Fong Ho; Zachary Philips; Michael R Batzloff; Michael F Good Journal: PLoS Pathog Date: 2016-12-27 Impact factor: 6.823
Authors: Andrew C Steer; Adam Jenney; Joseph Kado; Michael F Good; Michael Batzloff; Lepani Waqatakirewa; E Kim Mullholland; Jonathan R Carapetis Journal: Emerg Infect Dis Date: 2009-02 Impact factor: 6.883