| Literature DB >> 15231295 |
Ralph Rabkin1, Franz Schaefer.
Abstract
Both growth hormone (GH) and IGF-1 have major effects on normal kidney growth, structure and function and participate in the pathogenesis of certain kidney diseases. Furthermore when the kidneys fail there are profound changes in the circulating GH-IGF-1 system and the renal and systemic responses to these hormones. In this brief review we address the advances that have been made in our understanding of the relationship between growth hormone GH and IGF-1 and the kidney in health and the systemic and local perturbations that occur in kidney disease and identify key unanswered questions.Entities:
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Year: 2004 PMID： 15231295 DOI： 10.1016/j.ghir.2004.02.001
Source DB: PubMed Journal: Growth Horm IGF Res ISSN： 1096-6374 Impact factor: 2.372