Literature DB >> 15228498

Levosimendan interacts with potassium channel blockers in human saphenous veins.

József Höhn1, János Pataricza, András Petri, Gábor K Tóth, Adám Balogh, András Varró, Julius Gy Papp.   

Abstract

The involvement of potassium channels in the venodilating capacity of the inodilator levosimendan in human saphenous vein preparations was investigated. Levosimendan caused relaxation with 50% effective concentration (EC50) of 0.32 +/- 0.04 microM in isolated veins contracted by 5-hydroxytryptamine. Fifteen microM glibenclamide, a blocker of the ATP-sensitive potassium channels (K(ATP)), partially inhibited the relaxing effect of the inodilator. In the presence of iberiotoxin, the selective blocker of large conductance calcium-activated potassium channels (BK(Ca)), levosimendan induced contraction with EC50 of 0.21 +/- 0.06 microM. We presume that levosimendan dilates human saphenous veins by interacting with hyperpolarizing potassium channels (K(ATP) and BK(Ca)).

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Year:  2004        PMID： 15228498     DOI： 10.1111/j.1742-7843.2004.pto940603.x

Source DB:  PubMed          Journal:  Basic Clin Pharmacol Toxicol        ISSN： 1742-7835            Impact factor:   4.080


  11 in total

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