Literature DB >> 15227161

Severe neutropenia consequent to sustained-release procainamide.

M Mellino1, J Hogan, H C Taylor.   

Abstract

A patient with reversible severe neutropenia and relative eosinophilia caused by sustained-release procainamide is described. Significant early and very late complications of therapy with procainamide preparations have been rarely described so far. The important pharmacokinetic aspects of sustained release procainamide are discussed, and the postulated mechanisms of induction of blood dyscrasias are reviewed.

Entities:  

Year:  1983        PMID： 15227161      PMCID： PMC341612     

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN： 0730-2347


  7 in total

1.  Procainamide dosage schedules, plasma concentrations, and clinical effects.

Authors:  J Koch-Weser; S W Klein
Journal:  JAMA       Date:  1971-03-01       Impact factor: 56.272

2.  Severe transient pancytopenia associated with procainamide ingestion.

Authors:  A Z Bluming; D Plotkin; P Rosen; A R Thiessen
Journal:  JAMA       Date:  1976-11-29       Impact factor: 56.272

3.  Pharmacokinetics of procainamide intravenously and orally as conventional and slow-release tablets.

Authors:  C Graffner; G Johnsson; J Sjögren
Journal:  Clin Pharmacol Ther       Date:  1975-04       Impact factor: 6.875

4.  Agranulocytosis associated with procainamide therapy--report of a case.

Authors:  R A Prince; B T Brown; A I Jacknowitz
Journal:  Am J Hosp Pharm       Date:  1977-12

5.  Reversible severe anaemia and granulocytopenia caused by procainamide. A case report.

Authors:  R J van Beek; R Bieger; G J den Ottolander
Journal:  Scand J Haematol       Date:  1978-08

6.  Maintenance therapy with a new retard tablet preparation of procainamide.

Authors:  V Hansteen; K H Landmark; D Fremstad; S G Dahl; S Jacobsen; A A Marthinsen; T Waaler; K Frislid; P K Lunde
Journal:  Am Heart J       Date:  1976-07       Impact factor: 4.749

7.  Efficacy, plasma concentrations and adverse effects of a new sustained release procainamide preparation.

Authors:  E G Giardina; P E Fenster; J T Bigger; M Mayersohn; D Perrier; F I Marcus
Journal:  Am J Cardiol       Date:  1980-11       Impact factor: 2.778
  7 in total

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