| Literature DB >> 15226504 |
Steven V Ley1, Alessandra Antonello, Emily P Balskus, David T Booth, Søren B Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M Myers, Steven F Oliver, Oliver Simic, Martin D Smith, Helmer Søhoel, Alison J A Woolford.
Abstract
The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.Entities:
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Year: 2004 PMID： 15226504 PMCID： PMC514437 DOI： 10.1073/pnas.0403300101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205