Literature DB >> 15225841

Why "Vitamin D" is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids.

Reinhold Vieth1.   

Abstract

Official nutrition committee reports in both North America and Europe now state that Vitamin D is more of a hormone than a nutrient. These statements are wrong, and do not reflect the definitions of either vitamin or hormone. Researchers often compound the problem by referring to calcitriol or other deltanoids as "Vitamin D". These things have serious consequences: (1) The literature is burdened by an ongoing confusion that presumes that the reader will somehow "know" what the writer refers to by "Vitamin D". (2) Medical practitioners not familiar with the ambiguities administer Vitamin D inappropriately when calcitriol or a deltanoid analog would be correct, or vice versa. (3) Attempts to promote Vitamin D nutrition are hindered by alarmist responses justifiably associated with the widespread administration of any hormone. Vitamin D is a vitamin in the truest sense of the word, because "insufficient amounts in the diet may cause deficiency diseases". The term, prohormone, is not relevant to the Vitamin D system, but 25-hydroxy-Vitamin D (calcidiol) is appropriately described as a prehormone, i.e. a glandular secretory product, having little or no inherent biologic potency, that is converted peripherally to an active hormone.

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Year:  2004        PMID: 15225841     DOI: 10.1016/j.jsbmb.2004.03.037

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN: 0960-0760            Impact factor:   4.292


  15 in total

Review 1.  There is no lower threshold level for parathyroid hormone as 25-hydroxyvitamin D concentrations increase.

Authors:  R Vieth; G El-Hajj Fuleihan
Journal:  J Endocrinol Invest       Date:  2005-02       Impact factor: 4.256

2.  Limited availability of nutritional vitamin D causing inappropriate treatment of vitamin D deficiency rickets with a response resembling pseudohypoparathyroidism type II in a Japanese patient.

Authors:  Y Inamo
Journal:  J Endocrinol Invest       Date:  2005-10       Impact factor: 4.256

Review 3.  Resurgence of vitamin D: Old wine in new bottle.

Authors:  Raju Vaishya; Vipul Vijay; Amit Kumar Agarwal; Jabed Jahangir
Journal:  J Clin Orthop Trauma       Date:  2015-03-26

Review 4.  [Nutrition and mental diseases : Focus depressive disorders].

Authors:  L Libuda; J Antel; J Hebebrand; M Föcker
Journal:  Nervenarzt       Date:  2017-01       Impact factor: 1.214

Review 5.  Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons.

Authors:  Matteo Cesari; Raffaele Antonelli Incalzi; Valentina Zamboni; Marco Pahor
Journal:  Geriatr Gerontol Int       Date:  2010-12-06       Impact factor: 2.730

Review 6.  Vitamin D and mental health in children and adolescents.

Authors:  Manuel Föcker; Jochen Antel; Stefanie Ring; Denise Hahn; Özlem Kanal; Dana Öztürk; Johannes Hebebrand; Lars Libuda
Journal:  Eur Child Adolesc Psychiatry       Date:  2017-02-08       Impact factor: 4.785

Review 7.  Vitamin D in health and disease: current perspectives.

Authors:  Ran Zhang; Declan P Naughton
Journal:  Nutr J       Date:  2010-12-08       Impact factor: 3.271

8.  Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis.

Authors:  Michelle C Mann; Amy J Hobbs; Brenda R Hemmelgarn; Derek J Roberts; Sofia B Ahmed; Doreen M Rabi
Journal:  Clin Kidney J       Date:  2014-12-02

Review 9.  Vitamin D and airway infections: a European perspective.

Authors:  Armin Zittermann; Stefan Pilz; Harald Hoffmann; Winfried März
Journal:  Eur J Med Res       Date:  2016-03-24       Impact factor: 2.175

10.  The VITAH trial VITamin D supplementation and cardiac Autonomic tone in Hemodialysis: a blinded, randomized controlled trial.

Authors:  Michelle C Mann; Derek V Exner; Brenda R Hemmelgarn; David A Hanley; Tanvir C Turin; Jennifer M MacRae; Sofia B Ahmed
Journal:  BMC Nephrol       Date:  2014-08-06       Impact factor: 2.388

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