Literature DB >> 15225736

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents.

Ahmed Kamal1, O Srinivas, P Ramulu, G Ramesh, P Praveen Kumar.   

Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.

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Year:  2004        PMID: 15225736     DOI: 10.1016/j.bmcl.2004.04.087

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis of acridines by the [4 + 2] annulation of arynes and 2-aminoaryl ketones.

Authors:  Donald C Rogness; Richard C Larock
Journal:  J Org Chem       Date:  2010-04-02       Impact factor: 4.354

2.  10-(4-Chloro-phen-yl)-9-(4-fluoro-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.

Authors:  Ling-Ling Zhao; Da Teng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-16
  2 in total

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