Literature DB >> 15225735

Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation.

Seung Wook Ham1, Jong-In Choe, Mei-Fang Wang, Vincent Peyregne, Brian I Carr.   

Abstract

We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

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Year:  2004        PMID： 15225735     DOI： 10.1016/j.bmcl.2004.05.009

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

Authors:  Shahar Keinan; William D Paquette; John J Skoko; David N Beratan; Weitao Yang; Sunita Shinde; Paul A Johnston; John S Lazo; Peter Wipf
Journal:  Org Biomol Chem       Date:  2008-07-15       Impact factor: 3.876

2.  Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells.

Authors:  Shaojun Yang; Yi-Hua Jan; Vladimir Mishin; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Journal:  Chem Res Toxicol       Date:  2017-06-26       Impact factor: 3.739

3.  Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells.

Authors:  Shaojun Yang; Yi-Hua Jan; Joshua P Gray; Vladimir Mishin; Diane E Heck; Debra L Laskin; Jeffrey D Laskin
Journal:  J Biol Chem       Date:  2013-05-02       Impact factor: 5.157

4.  Differential Proliferation Effect of the Newly Synthesized Valine, Tyrosine and Tryptophan-Naphthoquinones in Immortal and Tumorigenic Cervical Cell Lines.

Authors:  Sergio Córdova-Rivas; Jorge Gustavo Araujo-Huitrado; Ernesto Rivera-Avalos; Ismailia L Escalante-García; Sergio M Durón-Torres; Yamilé López-Hernández; Hiram Hernández-López; Lluvia López; Denisse de Loera; Jesús Adrián López
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

5.  Synthesis of Amino Acid-Naphthoquinones and In Vitro Studies on Cervical and Breast Cell Lines.

Authors:  Ernesto Rivera-Ávalos; Denisse de Loera; Jorge Gustavo Araujo-Huitrado; Ismailia Leilani Escalante-García; Miguel Antonio Muñoz-Sánchez; Hiram Hernández; Jesús Adrián López; Lluvia López
Journal:  Molecules       Date:  2019-11-25       Impact factor: 4.411

6.  In vitro Activation of heme oxygenase-2 by menadione and its analogs.

Authors:  Dragic Vukomanovic; Mona N Rahman; Yaroslav Bilokin; Andriy G Golub; James F Brien; Walter A Szarek; Zongchao Jia; Kanji Nakatsu
Journal:  Med Gas Res       Date:  2014-02-18
  6 in total

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