| Literature DB >> 15225734 |
Rosa Arienzo1, David E Clark, Sue Cramp, Stephen Daly, Hazel J Dyke, Peter Lockey, Dennis Norman, Alan G Roach, Keith Stuttle, Maxine Tomlinson, Melanie Wong, Stephen P Wren.
Abstract
A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15225734 DOI： 10.1016/j.bmcl.2004.05.051
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823