| Literature DB >> 15225717 |
Toshiki Murata1, Mitsuyuki Shimada, Hiroshi Kadono, Sachiko Sakakibara, Takashi Yoshino, Tsutomu Masuda, Makoto Shimazaki, Takuya Shintani, Kinji Fuchikami, Kevin B Bacon, Karl B Ziegelbauer, Timothy B Lowinger.
Abstract
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IkappaB kinase beta (IKK-beta) inhibitors. Substitution of an aminoalkyl group for the aromatic group at the 4-position on the core pyridine ring resulted in a marked increase in both kinase enzyme and cellular potencies, and provided potent IKK-beta inhibitors with IC(50) values of below 100 nM.Entities:
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Year: 2004 PMID： 15225717 DOI： 10.1016/j.bmcl.2004.05.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823