| Literature DB >> 15225709 |
Brent R Stranix1, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Guy Sévigny, Jocelyn Yelle, Valérie Perron.
Abstract
A series of lysine sulfonamide analogues bearing a Nepsilon-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nalpha-(alkyl)-Nalpha-(sulfonamides)lysinol using alpha-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15225709 DOI： 10.1016/j.bmcl.2004.05.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823