| Literature DB >> 15225708 |
Samuel Chackalamannil1, Darío Doller, Robert McQuade, Vilma Ruperto.
Abstract
A number of analogs of the natural product himbacine were synthesized employing variations at the heterocyclic unit and the tether that links the heterocyclic unit to the tricyclic motif. Several of these analogs had M(2) affinity and M(1)/M(2) selectivity comparable to those of himbacine. The structural and stereochemical requirements of the heterocyclic unit for muscarinic binding are discussed in the light of these data.Entities:
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Year: 2004 PMID： 15225708 DOI： 10.1016/j.bmcl.2004.05.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823