Literature DB >> 15225705

Oxamides as novel NR2B selective NMDA receptor antagonists.

Gizella Barta-Szalai1, István Borza, Eva Bozó, Csilla Kiss, Béla Agai, Agnes Proszenyák, György M Keseru, Anikó Gere, Sándor Kolok, Kornél Galgóczy, Csilla Horváth, Sándor Farkas, György Domány.   

Abstract

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15225705     DOI： 10.1016/j.bmcl.2004.05.053

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Glutamate receptor ion channels: structure, regulation, and function.

Authors:  Stephen F Traynelis; Lonnie P Wollmuth; Chris J McBain; Frank S Menniti; Katie M Vance; Kevin K Ogden; Kasper B Hansen; Hongjie Yuan; Scott J Myers; Ray Dingledine
Journal:  Pharmacol Rev       Date:  2010-09       Impact factor: 25.468

Review 2.  Control of assembly and function of glutamate receptors by the amino-terminal domain.

Authors:  Kasper B Hansen; Hiro Furukawa; Stephen F Traynelis
Journal:  Mol Pharmacol       Date:  2010-07-21       Impact factor: 4.436

3.  Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.

Authors:  Pieter B Burger; Hongjie Yuan; Erkan Karakas; Matthew Geballe; Hiro Furukawa; Dennis C Liotta; James P Snyder; Stephen F Traynelis
Journal:  Mol Pharmacol       Date:  2012-05-17       Impact factor: 4.436

4.  Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

Authors:  Yesim A Tahirovic; Matthew Geballe; Ewa Gruszecka-Kowalik; Scott J Myers; Polina Lyuboslavsky; Phuong Le; Adam French; Hasan Irier; Woo-Baeg Choi; Keith Easterling; Hongjie Yuan; Lawrence J Wilson; Robert Kotloski; James O McNamara; Raymond Dingledine; Dennis C Liotta; Stephen F Traynelis; James P Snyder
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

5.  Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

Authors:  Cara A Mosley; Scott J Myers; Ernest E Murray; Rose Santangelo; Yesim A Tahirovic; Natalie Kurtkaya; Praseeda Mullasseril; Hongjie Yuan; Polina Lyuboslavsky; Phuong Le; Lawrence J Wilson; Manuel Yepes; Ray Dingledine; Stephen F Traynelis; Dennis C Liotta
Journal:  Bioorg Med Chem       Date:  2009-07-05       Impact factor: 3.641

6.  Oxalyl retro-peptide gelators. Synthesis, gelation properties and stereochemical effects.

Authors:  Janja Makarević; Milan Jokić; Leo Frkanec; Vesna Caplar; Nataša Sijaković Vujičić; Mladen Zinić
Journal:  Beilstein J Org Chem       Date:  2010-10-04       Impact factor: 2.883

7.  Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson's disease.

Authors:  Anne Michel; Patrick Downey; Jean-Marie Nicolas; Dieter Scheller
Journal:  PLoS One       Date:  2014-12-16       Impact factor: 3.240
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.