Literature DB >> 15225703

Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.

Charles Q Huang1, Keith M Wilcoxen, Dimitri E Grigoriadis, James R McCarthy, Chen Chen.   

Abstract

A series of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines was designed and synthesized as antagonists for the corticotrophin-releasing factor-1 (CRF(1)) receptor. Several compounds such as 20c (K(i)=10 nM) exhibited good binding affinities at the CRF(1) receptor. In addition, 20c had adequate solubility in water.

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Year:  2004        PMID： 15225703     DOI： 10.1016/j.bmcl.2004.05.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO₄ in aqueous media.

Authors:  Asem Satyapati Devi; Shunan Kaping; Jai Narain Vishwakarma
Journal:  Mol Divers       Date:  2015-05-28       Impact factor: 2.943

2.  N,N-Dimethyl-4-[5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]aniline.

Authors:  Shu-Wen Wang; Zheng-Quan Zuo; Wen-Long Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-01-04

3.  Synthesis of novel compounds as new potent tyrosinase inhibitors.

Authors:  Hooshang Hamidian
Journal:  Biomed Res Int       Date:  2013-10-22       Impact factor: 3.411
  3 in total

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