Literature DB >> 15225699

Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors.

Rima S Al-awar1, James E Ray, Kyle A Hecker, Sajan Joseph, Jianping Huang, Chuan Shih, Harold B Brooks, Charles D Spencer, Scott A Watkins, Richard M Schultz, Eileen L Considine, Margaret M Faul, Kevin A Sullivan, Stanley P Kolis, Michael A Carr, Faming Zhang.   

Abstract

The synthesis of novel aza-1,7-annulated indoles was achieved and these were converted to indolocarbazoles that proved to be potent kinase inhibitors. These compounds were also evaluated in a human colon carcinoma cell line and proved to be good antiproliferative agents.

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Year:  2004        PMID: 15225699     DOI: 10.1016/j.bmcl.2004.05.088

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

Authors:  Letian Kuai; Shao-En Ong; Jon M Madison; Xiang Wang; Jeremy R Duvall; Timothy A Lewis; Catherine J Luce; Sean D Conner; David A Pearlman; John L Wood; Stuart L Schreiber; Steven A Carr; Edward M Scolnick; Stephen J Haggarty
Journal:  Chem Biol       Date:  2011-07-29

2.  Methyl 2-(5-fluoro-1H-indol-3-yl)-2-oxoacetate.

Authors:  Shuping Wang; Huajiang Dong; Hong Chen; Kunpeng Zhu; Tieliang Zhu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-16
  2 in total

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