Literature DB >> 15225685

Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.

Timothy A Blizzard1, Frank DiNinno, Jerry D Morgan, Helen Y Chen, Jane Y Wu, Candido Gude, Seongkon Kim, Wanda Chan, Elizabeth T Birzin, Yi Tien Yang, Lee-Yuh Pai, Zhoupeng Zhang, Edward C Hayes, Carolyn A DaSilva, Wei Tang, Susan P Rohrer, James M Schaeffer, Milton L Hammond.   

Abstract

A series of benzoxathiin SERAMs with bicyclic amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.

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Year:  2004        PMID: 15225685     DOI: 10.1016/j.bmcl.2004.05.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist.

Authors:  Sébastien L Degorce; Michael S Bodnarchuk; James S Scott
Journal:  ACS Med Chem Lett       Date:  2019-07-18       Impact factor: 4.345

2.  Prediction of binding affinity for estrogen receptor alpha modulators using statistical learning approaches.

Authors:  Yonghua Wang; Yan Li; Jun Ding; Yuan Wang; Yaqing Chang
Journal:  Mol Divers       Date:  2008-07-26       Impact factor: 2.943

3.  Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.

Authors:  Susie Y Dai; Michael J Chalmers; John Bruning; Kelli S Bramlett; Harold E Osborne; Chahrzad Montrose-Rafizadeh; Robert J Barr; Yong Wang; Minmin Wang; Thomas P Burris; Jeffrey A Dodge; Patrick R Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-12       Impact factor: 11.205

4.  Synthesis of CHF2-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF2-pyrazolines.

Authors:  Yang Zheng; Xinling Yu; Songyang Lv; Pavel K Mykhailiuk; Qiang Ma; Li Hai; Yong Wu
Journal:  RSC Adv       Date:  2018-01-29       Impact factor: 4.036

  4 in total

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