| Literature DB >> 15225557 |
Wudayagiri Rajendra1, Arunmozhiarasi Armugam, Kandiah Jeyaseelan.
Abstract
The use of toxins as novel molecular probes to study the structure-function relationship of ion-channels and receptors as well as potential therapeutics in the treatment of wide variety of diseases is well documented. The high specificity and selectivity of these toxins have attracted a great deal of interest as candidates for drug development. This review highlights the involvement of the proteins and peptide toxins as well as non-proteinaceous compounds derived from both venomous and non-venomous animals, in anti-nociception and anti-inflammation. The possible mechanisms of these potential therapeutic agents and possible clinical applications in the treatment of pain and inflammation are also summarized.Entities:
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Year: 2004 PMID： 15225557 DOI： 10.1016/j.toxicon.2004.04.014
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033