Literature DB >> 15223495

Protocol for the successful treatment of venous ulcers.

Harold Brem1, Robert S Kirsner, Vincent Falanga.   

Abstract

Venous ulcers affect up to 2.5 million patients per year in the United States. Although not usually fatal, these chronic wounds severely affect patients' quality of life because of impaired mobility and substantial loss of productivity. Although venous ulcers are typically small initially, they are often undertreated, progressing to larger ulcers that are associated with more serious complications requiring more complex treatments. In this report we detail the pathogenesis of venous ulcers together with potential complications, including exudate, erythema, cellulitis, dermatitis, pain, and possible malignancy. The clinician's regimen should always include a wide range of treatment modalities to ensure comprehensive care and effective wound closure. The treatment modalities and specific protocol for venous ulcers are discussed, and include topical dressings, antibiotics, debridement, compression therapy, and cellular therapy. These treatment modalities, in combination with early recognition and regular monitoring using digital photography and planimetry measurements, will ensure rapid healing and minimize complications and cost.

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Year:  2004        PMID: 15223495     DOI: 10.1016/S0002-9610(03)00284-8

Source DB:  PubMed          Journal:  Am J Surg        ISSN: 0002-9610            Impact factor:   2.565


  34 in total

Review 1.  Comprehensive review of the clinical application of autologous mesenchymal stem cells in the treatment of chronic wounds and diabetic bone healing.

Authors:  Gerit D Mulder; Daniel K Lee; Nathan S Jeppesen
Journal:  Int Wound J       Date:  2012-02-28       Impact factor: 3.315

2.  Wound bed preparation of difficult wounds: an evolution of the principles of TIME.

Authors:  Claudio Ligresti; Filippo Bo
Journal:  Int Wound J       Date:  2007-03       Impact factor: 3.315

Review 3.  Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review.

Authors:  Lei Shi; Vincent Ronfard
Journal:  Int J Burns Trauma       Date:  2013-11-01

Review 4.  Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine.

Authors:  Eden Avishai; Kristina Yeghiazaryan; Olga Golubnitschaja
Journal:  EPMA J       Date:  2017-03-03       Impact factor: 6.543

5.  Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: a retrospective observational study.

Authors:  Giorgio Pajardi; Vicenzo Rapisarda; Francesco Somalvico; Andrea Scotti; Giulia Lo Russo; Francesco Ciancio; Arturo Sgrò; Manuela Nebuloni; Raffaele Allevi; Maria L Torre; Emilio Trabucchi; Mario Marazzi
Journal:  Int Wound J       Date:  2014-02-12       Impact factor: 3.315

6.  Secreted HoxA3 Promotes Epidermal Proliferation and Angiogenesis in Genetically Modified Three-Dimensional Composite Skin Constructs.

Authors:  Jennifer H Kuo; Ileana Cuevas; Amy Chen; Ashley Dunn; Mauricio Kuri; Nancy Boudreau
Journal:  Adv Wound Care (New Rochelle)       Date:  2014-10-01       Impact factor: 4.730

7.  IQGAP1 promotes the phenotypic switch of vascular smooth muscle by myocardin pathway: a potential target for varicose vein.

Authors:  Xianchen Huang; Yiqi Jin; Dayong Zhou; Guoxiong Xu; Jian Huang; Liming Shen
Journal:  Int J Clin Exp Pathol       Date:  2014-09-15

Review 8.  The science of compression therapy for chronic venous insufficiency edema.

Authors:  Heather Hettrick
Journal:  J Am Col Certif Wound Spec       Date:  2009-05-01

Review 9.  Regenerative Medicine: Charting a New Course in Wound Healing.

Authors:  Geoffrey C Gurtner; Mary Ann Chapman
Journal:  Adv Wound Care (New Rochelle)       Date:  2016-07-01       Impact factor: 4.730

10.  Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and titanium amplicon pyrosequencing and metagenomic approaches.

Authors:  Randall D Wolcott; Viktoria Gontcharova; Yan Sun; Scot E Dowd
Journal:  BMC Microbiol       Date:  2009-10-27       Impact factor: 3.605

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