Literature DB >> 15223182

Transfer of insulin lispro across the human placenta.

Gershon Holcberg, Marina Tsadkin-Tamir, Olga Sapir, Arnon Wiznizer, David Segal, Hana Polachek, Zvi Ben Zvi.   

Abstract

Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48 +/- microU in the maternal artery and 28 +/- 1 microU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836 +/- 220 microU.

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Year:  2004        PMID: 15223182     DOI: 10.1016/j.ejogrb.2003.10.006

Source DB:  PubMed          Journal:  Eur J Obstet Gynecol Reprod Biol        ISSN: 0301-2115            Impact factor:   2.435


  4 in total

Review 1.  Insulin analogues in the management of the pregnancy complicated by diabetes mellitus.

Authors:  Celeste P Durnwald; Mark B Landon
Journal:  Curr Diab Rep       Date:  2011-02       Impact factor: 4.810

Review 2.  The Placental Barrier: the Gate and the Fate in Drug Distribution.

Authors:  Nino Tetro; Sonia Moushaev; Miriam Rubinchik-Stern; Sara Eyal
Journal:  Pharm Res       Date:  2018-02-23       Impact factor: 4.200

Review 3.  Insulin lispro: a review of its use in the management of diabetes mellitus.

Authors:  Dene Simpson; Paul L McCormack; Gillian M Keating; Katherine A Lyseng-Williamson
Journal:  Drugs       Date:  2007       Impact factor: 9.546

Review 4.  Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation.

Authors:  Francisco Westermeier; Pablo J Sáez; Roberto Villalobos-Labra; Luis Sobrevia; Marcelo Farías-Jofré
Journal:  Biomed Res Int       Date:  2014-06-30       Impact factor: 3.411

  4 in total

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