Literature DB >> 1522219

Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H).

A E Gharavi1, L R Sammaritano, J Wen, K B Elkon.   

Abstract

A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.

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Year:  1992        PMID： 1522219      PMCID： PMC329971          DOI： 10.1172/JCI115927

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  40 in total

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Journal:  J Immunol       Date:  1979-03       Impact factor: 5.422

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Journal:  Lancet       Date:  1971-07-17       Impact factor: 79.321

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Journal:  Lancet       Date:  1983-10-08       Impact factor: 79.321

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Authors:  A E Gharavi; E N Harris; R A Asherson; G R Hughes
Journal:  Ann Rheum Dis       Date:  1987-01       Impact factor: 19.103

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Journal:  Br J Haematol       Date:  1987-04       Impact factor: 6.998

10.  Crossreactivity of antiphospholipid antibodies.

Authors:  E N Harris; A E Gharavi; S Loizou; G Derue; J K Chan; B M Patel; C G Mackworth-Young; C C Bunn; G R Hughes
Journal:  J Clin Lab Immunol       Date:  1985-01
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  25 in total

Review 1.  Association of anticardiolipin antibodies with vascular injury: possible mechanisms.

Authors:  Y S Haviv
Journal:  Postgrad Med J       Date:  2000-10       Impact factor: 2.401

Review 2.  Physiopathology of thrombosis induced by antiphospholipid antibodies.

Authors:  J M Zini
Journal:  Clin Rev Allergy Immunol       Date:  1995       Impact factor: 8.667

3.  Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein.

Authors:  S Hörkkö; E Miller; E Dudl; P Reaven; L K Curtiss; N J Zvaifler; R Terkeltaub; S S Pierangeli; D W Branch; W Palinski; J L Witztum
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

4.  Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome.

Authors:  Miri Blank; Ilan Krause; Mati Fridkin; Nathan Keller; Juri Kopolovic; Iris Goldberg; Ana Tobar; Yehuda Shoenfeld
Journal:  J Clin Invest       Date:  2002-03       Impact factor: 14.808

5.  Antiphospholipid Antibody Syndrome.

Authors:  Elena Cucurull; Azzudin E. Gharavi; Yamini Menon; Wendell A. Wilson
Journal:  Curr Treat Options Cardiovasc Med       Date:  2003-04

6.  Exposure to topical bovine thrombin during surgery elicits a response against the xenogeneic carbohydrate galactose alpha1-3galactose.

Authors:  J G Schoenecker; R K Hauck; M C Mercer; W Parker; J H Lawson
Journal:  J Clin Immunol       Date:  2000-11       Impact factor: 8.317

Review 7.  Antiphospholipid antibodies and the antiphospholipid syndrome.

Authors:  E N Harris; S S Pierangeli
Journal:  Springer Semin Immunopathol       Date:  1994

8.  Preventing antiphospholipid antibody-induced fetal loss: a new idea.

Authors:  M D Lockshin
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

Review 9.  The antiphospholipid syndrome. Diagnosis, management, and pathogenesis.

Authors:  E N Harris
Journal:  Clin Rev Allergy Immunol       Date:  1995       Impact factor: 8.667

10.  Activation of cultured vascular endothelial cells by antiphospholipid antibodies.

Authors:  R Simantov; J M LaSala; S K Lo; A E Gharavi; L R Sammaritano; J E Salmon; R L Silverstein
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808
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