Literature DB >> 15220917

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.

Young-Kwon Hong1, Kimberly Foreman, Jay W Shin, Satoshi Hirakawa, Christine L Curry, David R Sage, Towia Libermann, Bruce J Dezube, Joyce D Fingeroth, Michael Detmar.   

Abstract

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

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Year:  2004        PMID： 15220917     DOI： 10.1038/ng1383

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  137 in total

Review 1.  Virus-encoded microRNAs.

Authors:  Adam Grundhoff; Christopher S Sullivan
Journal:  Virology       Date:  2011-01-31       Impact factor: 3.616

Review 2.  The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.

Authors:  Mary E Ballestas; Kenneth M Kaye
Journal:  Future Microbiol       Date:  2011-12       Impact factor: 3.165

3.  Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV.

Authors:  Tiffany Jones; Fengchun Ye; Roble Bedolla; Yufei Huang; Jia Meng; Liwu Qian; Hongyi Pan; Fuchun Zhou; Rosalie Moody; Brent Wagner; Mazen Arar; Shou-Jiang Gao
Journal:  J Clin Invest       Date:  2012-02-01       Impact factor: 14.808

Review 4.  The new era of the lymphatic system: no longer secondary to the blood vascular system.

Authors:  Inho Choi; Sunju Lee; Young-Kwon Hong
Journal:  Cold Spring Harb Perspect Med       Date:  2012-04       Impact factor: 6.915

5.  Kaposi sarcoma involving the gastrointestinal tract.

Authors:  Manish Arora; Eric M Goldberg
Journal:  Gastroenterol Hepatol (N Y)       Date:  2010-07

6.  miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo.

Authors:  Deena M Leslie Pedrioli; Terhi Karpanen; Vasilios Dabouras; Giorgia Jurisic; Glenn van de Hoek; Jay W Shin; Daniela Marino; Roland E Kälin; Sebastian Leidel; Paolo Cinelli; Stefan Schulte-Merker; André W Brändli; Michael Detmar
Journal:  Mol Cell Biol       Date:  2010-05-17       Impact factor: 4.272

7.  Kaposi's sarcoma and human dermal microvascular endothelial cells infected with Kaposi's sarcoma-associated herpesvirus express CCL21.

Authors:  Makoto Sugaya; Stacy Reed; Patrick P Rose; Stacy de la Motte; Camilo M Raggo; Stephen E Kurtz; Ashlee V Moses; Klaus Früh; Andrew Blauvelt
Journal:  J Dermatol Sci       Date:  2010-12-05       Impact factor: 4.563

Review 8.  Targeted therapy for Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus.

Authors:  Dirk P Dittmer; Susan E Krown
Journal:  Curr Opin Oncol       Date:  2007-09       Impact factor: 3.645

9.  mTOR inhibitors block Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis.

Authors:  Debasmita Roy; Sang-Hoon Sin; Amy Lucas; Raman Venkataramanan; Ling Wang; Anthony Eason; Veenadhari Chavakula; Isaac B Hilton; Kristen M Tamburro; Blossom Damania; Dirk P Dittmer
Journal:  Cancer Res       Date:  2013-02-04       Impact factor: 12.701

10.  Kaposi's sarcoma-associated herpesvirus suppression of DUSP1 facilitates cellular pathogenesis following de novo infection.

Authors:  Zhiqiang Qin; Lu Dai; Michael Defee; Victoria J Findlay; Dennis K Watson; Bryan P Toole; Jennifer Cameron; Francesca Peruzzi; Keith Kirkwood; Chris Parsons
Journal:  J Virol       Date:  2012-10-24       Impact factor: 5.103
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