OBJECTIVE: To report the concomitant presentation of keratoconus and macular corneal dystrophy in two cases. METHODS: Two siblings with concomitant keratoconus and macular corneal dystrophy are presented. Complete ophthalmologic examination and computerized videokeratography were performed in both patients. Case 1 underwent penetrating keratoplasty in both eyes sequentially; histopathologic examination of excised corneal buttons with special stains was performed. Case 2 was observed. RESULTS: Both patients manifested typical signs and topographic evidence of keratoconus associated with macular dystrophy. Histopathologic studies in case 1 confirmed the same clinical diagnosis. CONCLUSION: To our knowledge, this is the first report of such a concurrence in the English literature and could lead to further studies on the possible pathophysiologic or genetic link between these 2 entities.
OBJECTIVE: To report the concomitant presentation of keratoconus and macular corneal dystrophy in two cases. METHODS: Two siblings with concomitant keratoconus and macular corneal dystrophy are presented. Complete ophthalmologic examination and computerized videokeratography were performed in both patients. Case 1 underwent penetrating keratoplasty in both eyes sequentially; histopathologic examination of excised corneal buttons with special stains was performed. Case 2 was observed. RESULTS: Both patients manifested typical signs and topographic evidence of keratoconus associated with macular dystrophy. Histopathologic studies in case 1 confirmed the same clinical diagnosis. CONCLUSION: To our knowledge, this is the first report of such a concurrence in the English literature and could lead to further studies on the possible pathophysiologic or genetic link between these 2 entities.
Authors: L Dudakova; M Palos; M Svobodova; J Bydzovsky; L Huna; K Jirsova; A J Hardcastle; S J Tuft; P Liskova Journal: Eye (Lond) Date: 2014-08-01 Impact factor: 3.775