Literature DB >> 15220005

Genetic dissection of antigen receptor induced-NF-kappaB activation.

Zhi-Wei Li1, Robert C Rickert, Michael Karin.   

Abstract

NF-kappaB is a master transcription factor in the immune system. It regulates various aspects of immune cell development, homeostasis, survival and function. It is in these contexts that the signaling pathways leading to NF-kappaB activation are best understood. This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis of mice lacking specific signaling intermediates.

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Year:  2004        PMID： 15220005     DOI： 10.1016/j.molimm.2004.04.012

Source DB:  PubMed          Journal:  Mol Immunol        ISSN： 0161-5890            Impact factor:   4.407


  11 in total

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