Literature DB >> 15219943

Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina.

Lee E Moore1, John K Wiencke, Michael N Bates, Shichun Zheng, Omar A Rey, Allan H Smith.   

Abstract

We investigated the role of glutathione S-transferase (GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina. Buccal cell DNA was obtained from 106 cases and 109 controls. The strongest evidence was for an interaction between NQO1 genotype and smoking. For ever smoking vs. never smoking the odds ratio was 8.6 (95% confidence interval (CI) 2.7-27), in the CC genotype, and 1.3 (95% CI 0.5-3.5) in the CT and TT genotypes combined. Also, elevated bladder cancer risks associated with GSTM1 and GSTT1 null genotypes were found in smokers. Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer.

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Year:  2004        PMID： 15219943     DOI： 10.1016/j.canlet.2004.04.011

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  32 in total

1.  NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.

Authors:  Montserrat García-Closas; Núria Malats; Debra Silverman; Mustafa Dosemeci; Manolis Kogevinas; David W Hein; Adonina Tardón; Consol Serra; Alfredo Carrato; Reina García-Closas; Josep Lloreta; Gemma Castaño-Vinyals; Meredith Yeager; Robert Welch; Stephen Chanock; Nilanjan Chatterjee; Sholom Wacholder; Claudine Samanic; Montserrat Torà; Francisco Fernández; Francisco X Real; Nathaniel Rothman
Journal:  Lancet       Date:  2005 Aug 20-26       Impact factor: 79.321

2.  Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.

Authors:  Yu Chen; Faruque Parvez; Mary Gamble; Tariqul Islam; Alauddin Ahmed; Maria Argos; Joseph H Graziano; Habibul Ahsan
Journal:  Toxicol Appl Pharmacol       Date:  2009-01-27       Impact factor: 4.219

3.  Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer.

Authors:  João Paulo Souto Grando; Hellen Kuasne; Roberta Losi-Guembarovski; Iara Sant'ana Rodrigues; Henrique Mitsu Matsuda; Paulo Emílio Fuganti; Emerson Pereira Gregório; Farid Libos Júnior; Rodrigo Paes de Menezes; Marco Aurélio de Freitas Rodrigues; Ilce Mara de Syllos Cólus
Journal:  Clin Exp Med       Date:  2008-11-01       Impact factor: 3.984

4.  Genetic susceptibility of methylenetetrahydrofolate reductase (MTHFR) gene C677T, A1298C, and G1793A polymorphisms with risk for bladder transitional cell carcinoma in men.

Authors:  Mohammad Reza Safarinejad; Nayyer Shafiei; Shiva Safarinejad
Journal:  Med Oncol       Date:  2010-10-29       Impact factor: 3.064

Review 5.  Association between MTHFR Ala222Val (rs1801133) polymorphism and bladder cancer susceptibility: a systematic review and meta-analysis.

Authors:  Kai Li; Yong ping Hu; Zecheng Yang; Tongxin Sun
Journal:  Tumour Biol       Date:  2013-05-07

6.  Association between GSTM1 copy number, promoter variants and susceptibility to urinary bladder cancer.

Authors:  Xuemei Zhang; Jie Lin; Xifeng Wu; Zhongning Lin; Baitang Ning; Susan Kadlubar; Fred F Kadlubar
Journal:  Int J Mol Epidemiol Genet       Date:  2012-08-31

Review 7.  Arsenic exposure in Latin America: biomarkers, risk assessments and related health effects.

Authors:  Tyler R McClintock; Yu Chen; Jochen Bundschuh; John T Oliver; Julio Navoni; Valentina Olmos; Edda Villaamil Lepori; Habibul Ahsan; Faruque Parvez
Journal:  Sci Total Environ       Date:  2011-11-26       Impact factor: 7.963

8.  Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.

Authors:  Meilin Wang; Haixia Zhu; Guangbo Fu; Miaomiao Wang; Zhizhong Zhang; Qiang Lu; Shizhi Wang; Zhengdong Zhang
Journal:  Clin Exp Med       Date:  2008-09-25       Impact factor: 3.984

9.  Genetic polymorphisms of glutathione S-transferase T1 and bladder cancer risk: a meta-analysis.

Authors:  Fang-Fang Zeng; Sheng-Yuan Liu; Wen Wei; Song-Po Yao; Shui Zhu; Ke-Shen Li; Gang Wan; Hai-Tao Zhang; Min Zhong; Bin-You Wang
Journal:  Clin Exp Med       Date:  2009-09-25       Impact factor: 3.984

10.  CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population.

Authors:  Ertan Altayli; Sezgin Gunes; Ali Faik Yilmaz; Serdar Goktas; Yuksel Bek
Journal:  Int Urol Nephrol       Date:  2008-08-09       Impact factor: 2.370
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