Literature DB >> 15219842

Effects of ursolic acid on different steps of the angiogenic process.

Casimiro Cárdenas1, Ana R Quesada, Miguel Angel Medina.   

Abstract

Ursolic acid is a triterpenoid with pleiotropic biological effects. In this report, we study the effects of ursolic acid on different key steps of angiogenesis. Our results show that ursolic acid is able to inhibit key steps of angiogenesis in vitro, including endothelial cell proliferation, migration, and differentiation. At the same time, it seems to stimulate other key steps of angiogenesis, such as extracellular matrix degradation by MMP-2 and urokinase. Although ursolic acid can inhibit in vivo angiogenesis in the CAM assay, the different signs of the effects it causes on different steps of angiogenesis force one to be cautious concerning its anti-angiogenic potential.

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Year:  2004        PMID： 15219842     DOI： 10.1016/j.bbrc.2004.05.183

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  19 in total

1.  Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

Authors:  Vanessa I S Mendes; Geoffrey A Bartholomeusz; Mary Ayres; Varsha Gandhi; Jorge A R Salvador
Journal:  Eur J Med Chem       Date:  2016-07-22       Impact factor: 6.514

2.  Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats.

Authors:  Iris Zeller; Dominik Wiedemann; Stefan Schwaiger; Marlies Stelzmüller; Simone Kreutmayer; Oliver Leberfing; Hermann Stuppner; David Bernhard
Journal:  Eur J Cardiothorac Surg       Date:  2012-05-02       Impact factor: 4.191

3.  Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications.

Authors:  Daniel Crístian Ferreira Soares; Diogo Coelho de Paula Oliveira; Luciola Silva Barcelos; Alan Sales Barbosa; Lorena Carla Vieira; Danyelle M Townsend; Domenico Rubello; André Luis Branco de Barros; Lucienir Pains Duarte; Armando Silva-Cunha
Journal:  Biomed Pharmacother       Date:  2017-05-27       Impact factor: 6.529

4.  Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.

Authors:  Auxiliadora López-Jiménez; Melissa García-Caballero; Miguel Ángel Medina; Ana R Quesada
Journal:  Eur J Nutr       Date:  2011-12-16       Impact factor: 5.614

Review 5.  Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?

Authors:  Md Soriful Islam; Most Mauluda Akhtar; Andrea Ciavattini; Stefano Raffaele Giannubilo; Olga Protic; Milijana Janjusevic; Antonio Domenico Procopio; James H Segars; Mario Castellucci; Pasquapina Ciarmela
Journal:  Mol Nutr Food Res       Date:  2014-06-30       Impact factor: 5.914

Review 6.  Cancer prevention with promising natural products: mechanisms of action and molecular targets.

Authors:  Poyil Pratheeshkumar; Chakkenchath Sreekala; Zhuo Zhang; Amit Budhraja; Songze Ding; Young-Ok Son; Xin Wang; Andrew Hitron; Kim Hyun-Jung; Lei Wang; Jeong-Chae Lee; Xianglin Shi
Journal:  Anticancer Agents Med Chem       Date:  2012-12       Impact factor: 2.505

7.  Anticancer effect of ursolic acid stearoyl glucoside in chemically induced hepatocellular carcinoma.

Authors:  Imran Kazmi; Anil Raj Narooka; Muhammad Afzal; Rajbala Singh; Fahad A Al-Abbasi; Aftab Ahmad; Firoz Anwar
Journal:  J Physiol Biochem       Date:  2013-03-20       Impact factor: 4.158

8.  Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).

Authors:  Stefan Schwaiger; Iris Zeller; Petra Pölzelbauer; Sandra Frotschnig; Günther Laufer; Barbara Messner; Valerio Pieri; Hermann Stuppner; David Bernhard
Journal:  J Ethnopharmacol       Date:  2010-10-30       Impact factor: 4.360

9.  Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.

Authors:  Casimiro Cárdenas; Ana R Quesada; Miguel A Medina
Journal:  PLoS One       Date:  2011-08-09       Impact factor: 3.240

10.  The effects of ursolic acid on cytokine production via the MAPK pathways in leukemic T-cells.

Authors:  Narawan Kaewthawee; Sirikalaya Brimson
Journal:  EXCLI J       Date:  2013-02-08       Impact factor: 4.068
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