| Literature DB >> 15219286 |
Sonya Shortkroff1, Emanuela Binello, Xuping Zhu, David Gierga, Thomas S Thornhill, Ruth E Shefer, Alun G Jones, Jacquelyn C Yanch.
Abstract
This study assessed the treatment with boron neutron capture synovectomy of synovitis in the antigen-induced arthritis (AIA) model. A boron compound, potassium dodecahydrododeca-borate (K(2)B(12)H(12)), was injected into stifle joints of 24 AIA and 12 normal rabbits and activated by neutron bombardment of the joint to achieve doses from 800 to 81,000 RBE-cGy. Synovial ablation in the AIA joint was accomplished at doses of 6,000 to 7,000 RBE-cGy with no adverse effects to skin or extracapsular tissues.Entities:
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Year: 2004 PMID： 15219286 DOI： 10.1016/j.nucmedbio.2003.12.001
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408