Literature DB >> 1521924

Interleukin-6 (IL-6) in adjuvant arthritis of rats and its pharmacological modulation.

P Theisen-Popp1, H Pape, R Müller-Peddinghaus.   

Abstract

The levels of serum interleukin-6 (IL-6) were measured during the course of adjuvant arthritis (FAA) in male Lewis rats. In the course of the disease serum IL-6 levels increase with a clear correlation with morphologic disease signs. Additionally, the FAA-inducing antigen, heat-killed Mycobacterium tuberculosis, was found to be a strong inducer of IL-6 production by spleen cells in vitro. The effects of the anti-rheumatic drugs indometacin, dexamethasone, cyclophosphamide and cyclosporin A (CsA) on IL-6 levels during FAA were determined. Complete normalization of serum IL-6 levels was observed with dexamethasone, cyclophosphamide and CsA whereas indometacin only partly reduced serum IL-6 levels.

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Year:  1992        PMID： 1521924     DOI： 10.1016/0192-0561(92)90117-4

Source DB:  PubMed          Journal:  Int J Immunopharmacol        ISSN： 0192-0561


  13 in total

1.  Antirheumatic drug profiles evaluated in the adjuvant arthritis of rats by multiparameter analysis.

Authors:  P Theisen-Popp; R Müller-Peddinghaus
Journal:  Agents Actions       Date:  1994-08

2.  Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production.

Authors:  D R Haynes; S J Gadd; M W Whitehouse; G Mayrhofer; B Vernon-Roberts
Journal:  Inflamm Res       Date:  1996-04       Impact factor: 4.575

3.  Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.

Authors:  G D Anderson; S D Hauser; K L McGarity; M E Bremer; P C Isakson; S A Gregory
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

4.  Modulation of alpha 1-acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development.

Authors:  M Yiangou; C Konidaris; P Victoratos; L Hadjipetrou-Kourounakis
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

5.  Lack of causal relationship between inducibility/severity of adjuvant arthritis in the rat and disease associated changes in production of nitric oxide by macrophages.

Authors:  Z Zídek; D Franková; B Otová
Journal:  Ann Rheum Dis       Date:  1995-04       Impact factor: 19.103

6.  Wasting in adjuvant-induced arthritis and its relationship to plasma zinc, copper and liver metallothionein.

Authors:  A M Rofe; J C Philcox; D R Haynes; P Coyle
Journal:  Agents Actions       Date:  1994-08

7.  Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor.

Authors:  P Coyle; J C Philcox; A M Rofe
Journal:  Inflamm Res       Date:  1995-11       Impact factor: 4.575

8.  Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis.

Authors:  Dirk Pohlers; Angela Siegling; Eberhard Buchner; Carsten B Schmidt-Weber; Ernesta Palombo-Kinne; Frank Emmrich; Rolf Bräuer; Raimund W Kinne
Journal:  Arthritis Res Ther       Date:  2005-02-17       Impact factor: 5.156

9.  Suppression of adipogenesis by pathogenic seipin mutant is associated with inflammatory response.

Authors:  Wenjie Qiu; Kenneth Wee; Kosuke Takeda; Xuemei Lim; Shigeki Sugii; George K Radda; Weiping Han
Journal:  PLoS One       Date:  2013-03-08       Impact factor: 3.240

10.  Effects of triazolodiazepine on the production of interleukin-6 from murine spleen cells and rabbit synovial cells in vitro.

Authors:  D W Ju; Q Y Zheng; X T Cao; Q H Zheng; X J Guan; H B Wang
Journal:  Mediators Inflamm       Date:  1995       Impact factor: 4.711
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