| Literature DB >> 15218048 |
F J Bikker1, J E van der Wal, A J M Ligtenberg, J Mollenhauer, J M A de Blieck-Hogervorst, I van der Waal, A Poustka, A V Nieuw Amerongen.
Abstract
Salivary agglutinin (SAG) is encoded by the gene Deleted in Malignant Brain Tumors 1 (DMBT1) and represents the salivary variant of DMBT1 (DMBT1(SAG)). While SAG is a bona fide anti-caries factor, DMBT1 was proposed as a candidate tumor-suppressor for brain, digestive tract, and lung cancer. Though DMBT1(SAG) is expressed in the salivary glands, its expression in salivary gland tumors is unknown. Here we analyzed DMBT1(SAG) expression in 20 salivary gland tumors and 14 tumor-flanking tissues by immunohistochemistry. DMBT1(SAG) in salivary gland tumors resembles the changes of expression levels known from DMBT1 in tumors in other cancer types. Particularly, DMBT1(SAG) was up-regulated in 10/14 tumor-flanking tissues, and a strong staining of the luminal content in the tumor and/or the tumor-flanking tissue was observed in 14/20 cases. This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue.Entities:
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Year: 2004 PMID： 15218048 DOI： 10.1177/154405910408300711
Source DB: PubMed Journal: J Dent Res ISSN： 0022-0345 Impact factor: 6.116