| Literature DB >> 15217726 |
Adriana Parodi-Talice1, Rosario Durán, Nicolás Arrambide, Victoria Prieto, María Dolores Piñeyro, Otto Pritsch, Alfonso Cayota, Carlos Cerveñansky, Carlos Robello.
Abstract
Trypanosoma cruzi, the causative agent of Chagas disease, has evolved particular mechanisms of gene regulation. Gene expression is regulated firstly at post-transcriptional level. This feature makes proteomic methods a promising tool for studying adaptative changes in these parasites. In this work we generated a reproducible method for protein analysis by two-dimensional electrophoresis coupled to mass spectrometry, and a protein map for T. cruzi. Western-blot analysis supported the identity of some of the proteins. This work points to proteomic approach as a powerful tool to study differential expression, stress response or drug resistance in T. cruzi.Entities:
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Year: 2004 PMID： 15217726 DOI： 10.1016/j.ijpara.2004.05.002
Source DB: PubMed Journal: Int J Parasitol ISSN： 0020-7519 Impact factor: 3.981