Literature DB >> 15217279

Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.

Shugeng Cao1, Rebecca Clare Guza, James S Miller, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston.   

Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 microg/mL.

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Year:  2004        PMID： 15217279     DOI： 10.1021/np040058h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Screening of traditionally used endemic Soqotraen plants for cytotoxic activity.

Authors:  Nasser A Awadh Ali; Ramzi Mothana; Nasr Abdo Ghaleb; Ulrike Lindequist
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-06-10

2.  Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest.

Authors:  Yanpeng Hou; Shugeng Cao; Peggy Brodie; James S Miller; Chris Birkinshaw; Fidisoa Ratovoson; Roland Rakotondrajaona; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-12-29       Impact factor: 4.050

3.  Biodiversity conservation and drug discovery: Can they be combined? The Suriname and Madagascar experiences.

Authors:  Shugeng Cao; David G I Kingston
Journal:  Pharm Biol       Date:  2009-08-01       Impact factor: 3.503

4.  Untargeted Metabolomics Sheds Light on the Diversity of Major Classes of Secondary Metabolites in the Malpighiaceae Botanical Family.

Authors:  Helena Mannochio-Russo; Rafael F de Almeida; Wilhan D G Nunes; Paula C P Bueno; Andrés M Caraballo-Rodríguez; Anelize Bauermeister; Pieter C Dorrestein; Vanderlan S Bolzani
Journal:  Front Plant Sci       Date:  2022-04-14       Impact factor: 5.753

5.  Antioxidant activities of Lampaya medicinalis extracts and their main chemical constituents.

Authors:  Glauco Morales; Adrián Paredes
Journal:  BMC Complement Altern Med       Date:  2014-07-21       Impact factor: 3.659

6.  Differential Cytotoxic Potential of Acridocarpus orientalis Leaf and Stem Extracts with the Ability to Induce Multiple Cell Death Pathways.

Authors:  Sameera Omar Mohammed Saeed Balhamar; Neena Gopinathan Panicker; Shaima Akhlaq; Mohammed Mansoor Qureshi; Waqar Ahmad; Najeeb Ur Rehman; Liaqat Ali; Ahmed Al-Harrasi; Javid Hussain; Farah Mustafa
Journal:  Molecules       Date:  2019-11-03       Impact factor: 4.411

7.  Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra.

Authors:  Ramzi A Mothana; Ulrike Lindequist; Renate Gruenert; Patrick J Bednarski
Journal:  BMC Complement Altern Med       Date:  2009-03-25       Impact factor: 3.659
  7 in total

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