Literature DB >> 15217190

FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. II. Biological activities.

Hidetaka Hatori1, Toshihiro Shibata, Motoaki Nishikawa, Hirotsugu Ueda, Motohiro Hino, Takashi Fujii.   

Abstract

Novel cholesterol synthesis inhibitors FR171456 and FR173945 were isolated from the culture broth of Sporormiella minima No. 15604. FR171456 strongly inhibited the cholesterol synthesis and up-regulated the LDL-receptor expression in human hepatoma cell line Hep G2. Single oral administration of FR171456 inhibited in vivo hepatic sterol synthesis in rats. And FR171456 shows a significant serum cholesterol-lowering effect in a cholesterol fed rabbit model.

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Year:  2004        PMID： 15217190     DOI： 10.7164/antibiotics.57.260

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  2 in total

1.  FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Authors:  Stephen B Helliwell; Shantanu Karkare; Marc Bergdoll; Alain Rahier; Juliet R Leighton-Davis; Celine Fioretto; Thomas Aust; Ireos Filipuzzi; Mathias Frederiksen; John Gounarides; Dominic Hoepfner; Andreas Hofmann; Pierre-Eloi Imbert; Rolf Jeker; Richard Knochenmuss; Philipp Krastel; Anais Margerit; Klaus Memmert; Charlotte V Miault; N Rao Movva; Alban Muller; Hans-Ulrich Naegeli; Lukas Oberer; Vivian Prindle; Ralph Riedl; Sven Schuierer; Jessica A Sexton; Jianshi Tao; Trixie Wagner; Hong Yin; Juan Zhang; Silvio Roggo; Stefan Reinker; Christian N Parker
Journal:  Nat Commun       Date:  2015-10-12       Impact factor: 14.919

2.  A New Xanthone Glycoside from the Endolichenic Fungus Sporormiella irregularis.

Authors:  Bin-Jie Yang; Guo-Dong Chen; Yan-Jun Li; Dan Hu; Liang-Dong Guo; Ping Xiong; Hao Gao
Journal:  Molecules       Date:  2016-06-11       Impact factor: 4.411
  2 in total

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