Literature DB >> 15216351

A novel one-pot four-component access to tetrahydro-beta-carbolines by a coupling-amination-aza-annulation-Pictet-Spengler sequence (CAAPS).

Alexei S Karpov1, Thomas Oeser, Thomas J J Müller.   

Abstract

The four-component coupling-amination-aza-annulation-Pictet-Spengler (CAAPS) sequence of acid chlorides 1, terminal alkynes 2, tryptamine derivatives 6, and acryloyl chloride derivatives 4 represents a facile and rapid one-pot access to tetrahydro-beta-carbolines 7 in moderate to good yields.

Entities:  

Year:  2004        PMID: 15216351     DOI: 10.1039/b404559a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Emulating the logic of monoterpenoid alkaloid biogenesis to access a skeletally diverse chemical library.

Authors:  Song Liu; John S Scotti; Sergey A Kozmin
Journal:  J Org Chem       Date:  2013-08-27       Impact factor: 4.354

  1 in total

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