Literature DB >> 15215568

3Alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as blood-brain barrier permeator.

Momir Mikov1, Slavko Kevresan, Ksenija Kuhajda, Vida Jakovljević, Velibor Vasović.   

Abstract

The aim of the study was to test the efficacy of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as a blood-brain barrier (BBB) permeator by examining its effect on quinine uptake into the central nervous system in rats, analgesic action of morphine, and on the sleeping time induced by pentobarbital. The obtained results indicate that sodium 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate can be considered as modifier of BBB permeability, as it exhibited a promoting effect in all three tests. In the test of quinine uptake, methyl ester of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoic acid (included in the study for comparison) did not show a promoting effect, which can suggest its specific action.

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Year:  2004        PMID： 15215568

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN： 1230-6002


  10 in total

1.  Influence of bile acid derivates on tramadol analgesic effect in mice.

Authors:  V Vasovic; Sasa Vukmirovic; M Pjevic; I Mikov; M Mikov; V Jakovljevic
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2010-09       Impact factor: 2.441

2.  Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats.

Authors:  Mihalj Posa; Slavko Kevresan; Momir Mikov; Vera Cirin-Novta; Ksenija Kuhajda
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Apr-Jun       Impact factor: 2.441

Review 3.  Pharmacology of bile acids and their derivatives: absorption promoters and therapeutic agents.

Authors:  M Mikov; J P Fawcett; K Kuhajda; S Kevresan
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2006 Jul-Sep       Impact factor: 2.441

4.  Effect of 12-monoketocholic acid on modulation of analgesic action of morphine and tramadol.

Authors:  Ivan Kuhajda; Mihalj Posa; Vida Jakovljević; Vesna Ivetić; Momir Mikov
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2009 Apr-Jun       Impact factor: 2.441

5.  The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes.

Authors:  Momir Mikov; Hani Al-Salami; Svetlana Golocorbin-Kon; Ranko Skrbic; Aleksandar Raskovic; J Paul Fawcett
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2008 Jul-Sep       Impact factor: 2.441

Review 6.  Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles.

Authors:  Nebojša Pavlović; Svetlana Goločorbin-Kon; Maja Ðanić; Bojan Stanimirov; Hani Al-Salami; Karmen Stankov; Momir Mikov
Journal:  Front Pharmacol       Date:  2018-11-08       Impact factor: 5.810

Review 7.  Regulation of common neurological disorders by gut microbial metabolites.

Authors:  Jeongho Park; Chang H Kim
Journal:  Exp Mol Med       Date:  2021-12-02       Impact factor: 8.718

8.  Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat.

Authors:  Mladena Lalić-Popović; Velibor Vasović; Boris Milijašević; Svetlana Goločorbin-Kon; Hani Al-Salami; Momir Mikov
Journal:  J Diabetes Res       Date:  2013-03-13       Impact factor: 4.011

9.  Cefotaxime pharmacokinetics after oral application in the form of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate microvesicles in rat.

Authors:  Svetlana Golocorbin-Kon; Momir Mikov; Mousab Arafat; Zika Lepojevic; Ivan Mikov; Majda Sahman-Zaimovic; Zdenko Tomic
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2009 Jan-Mar       Impact factor: 2.569

10.  Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge.

Authors:  Gelareh Arzani; Azadeh Haeri; Marjan Daeihamed; Hamid Bakhtiari-Kaboutaraki; Simin Dadashzadeh
Journal:  Int J Nanomedicine       Date:  2015-07-29
  10 in total

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