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Literature DB >> 15215410

SDPMOD: an automated comparative modeling server for small disulfide-bonded proteins.

Lesheng Kong¹, Bernett Teck Kwong Lee, Joo Chuan Tong, Tin Wee Tan, Shoba Ranganathan.

Abstract

Small disulfide-bonded proteins (SDPs) are rich sources for therapeutic drugs. Designing drugs from these proteins requires three-dimensional structural information, which is only available for a subset of these proteins. SDPMOD addresses this deficit in structural information by providing a freely available automated comparative modeling service to the research community. For expert users, SDPMOD offers a manual mode that permits the selection of a desired template as well as a semi-automated mode that allows users to select the template from a suggested list. Besides the selection of templates, expert users can edit the target-template alignment, thus allowing further customization of the modeling process. Furthermore, the web service provides model stereochemical quality evaluation using PROCHECK. SDPMOD is freely accessible to academic users via the web interface at http://proline.bic.nus.edu.sg/sdpmod.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15215410 PMCID： PMC441532 DOI： 10.1093/nar/gkh394

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

14 in total

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