Literature DB >> 15215374

The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences.

Wolfgang Helmberg1, Raymond Dunivin, Michael Feolo.   

Abstract

The dbMHC resource (http://www.ncbi.nlm.nih.gov/mhc/sbt.cgi?cmd=main) at the National Center for Biotechnology Information (NCBI) has developed an online tool for evaluating the allelic composition of sequencing-based typing (SBT) results of cDNA or genomic sequences. Whether the samples are heterozygous, haploid or a combination of the two, they can be compared with two up-to-date databases of all known alleles of several human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) loci. The results of the submission are returned as a table of potential allele hits, along with the respective base changes and an interactive sequence viewer for close examination of the alignment.

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Year:  2004        PMID： 15215374      PMCID： PMC441562          DOI： 10.1093/nar/gkh424

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


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