Literature DB >> 15215267

"Anti-aging" is an oxymoron.

Leonard Hayflick1.   

Abstract

No intervention will slow, stop, or reverse the aging process in humans. Whether anti-aging medicine is, or is not, a legitimate science is completely dependent upon the definition of key terms that define the finitude of life: longevity determination, aging, and age-associated diseases. Only intervention in the latter by humans has been shown to affect life expectancy. When it becomes possible to slow, stop, or reverse the aging process in the simpler molecules that compose inanimate objects, such as machines, then that prospect may become tenable for the complex molecules that compose life forms. Most of the resources available under the rubric "aging research" are not used for that purpose at all, thus making the likelihood of intervention in the process even more remote. If age changes are the greatest risk factor for age-associated diseases (an almost universal belief), then why is the study of aging virtually neglected?

Entities:  

Mesh:

Year:  2004        PMID: 15215267     DOI: 10.1093/gerona/59.6.b573

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN: 1079-5006            Impact factor:   6.053


  15 in total

Review 1.  How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging.

Authors:  David Karasik
Journal:  Age (Dordr)       Date:  2010-07-02

2.  Resistance to debate on how to postpone ageing is delaying progress and costing lives. Open discussions in the biogerontology community would attract public interest and influence funding policy.

Authors:  Aubrey D N J de Grey
Journal:  EMBO Rep       Date:  2005-07       Impact factor: 8.807

3.  The scientific quest for lasting youth: prospects for curing aging.

Authors:  João Pedro de Magalhães
Journal:  Rejuvenation Res       Date:  2014-10       Impact factor: 4.663

Review 4.  Target population for clinical trials on sarcopenia.

Authors:  M Cesari; M Pahor
Journal:  J Nutr Health Aging       Date:  2008 Aug-Sep       Impact factor: 4.075

5.  The neurocognitive correlates of brain entropy estimated by resting state fMRI.

Authors:  Ze Wang
Journal:  Neuroimage       Date:  2021-02-20       Impact factor: 6.556

6.  Andropause and the development of cardiovascular disease presentation-more than an epi-phenomenon.

Authors:  Ernst R Schwarz; Anita Phan; Robert D Willix
Journal:  J Geriatr Cardiol       Date:  2011-03       Impact factor: 3.327

7.  Covariance statistics and network analysis of brain PET imaging studies.

Authors:  Mattia Veronese; Lucia Moro; Marco Arcolin; Ottavia Dipasquale; Gaia Rizzo; Paul Expert; Wasim Khan; Patrick M Fisher; Claus Svarer; Alessandra Bertoldo; Oliver Howes; Federico E Turkheimer
Journal:  Sci Rep       Date:  2019-02-21       Impact factor: 4.379

Review 8.  The aging process and potential interventions to extend life expectancy.

Authors:  Matteo Tosato; Valentina Zamboni; Alessandro Ferrini; Matteo Cesari
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458

9.  Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both.

Authors:  Leonard Hayflick
Journal:  PLoS Genet       Date:  2007-12       Impact factor: 5.917

Review 10.  Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.

Authors:  Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2013-11-15       Impact factor: 4.534

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