Literature DB >> 15215128

Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.

N S Zeidner1, K S Brandt, E Dadey, M C Dolan, C Happ, J Piesman.   

Abstract

The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.

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Year:  2004        PMID： 15215128      PMCID： PMC434223          DOI： 10.1128/AAC.48.7.2697-2699.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Lyme disease--United States, 2000.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2002-01-18       Impact factor: 17.586

2.  How can we prevent Lyme disease?

Authors:  Edward B Hayes; Joseph Piesman
Journal:  N Engl J Med       Date:  2003-06-12       Impact factor: 91.245

3.  Simple and reliable method of doxycycline determination in human plasma and biological tissues.

Authors:  B Axisa; A R Naylor; P R Bell; M M Thompson
Journal:  J Chromatogr B Biomed Sci Appl       Date:  2000-07-21

Review 4.  Sustained-release injectables formed in situ and their potential use for veterinary products.

Authors:  Christian Matschke; Ute Isele; Peter van Hoogevest; Alfred Fahr
Journal:  J Control Release       Date:  2002-12-13       Impact factor: 9.776

Review 5.  Doxycycline revisited.

Authors:  N Joshi; D Q Miller
Journal:  Arch Intern Med       Date:  1997-07-14

6.  Babesia microti and Borrelia bissettii transmission by Ixodes spinipalpis ticks among prairie voles, Microtus ochrogaster, in Colorado.

Authors:  T R Burkot; B S Schneider; N J Pieniazek; C M Happ; J S Rutherford; S B Slemenda; E Hoffmeister; G O Maupin; N S Zeidner
Journal:  Parasitology       Date:  2000-12       Impact factor: 3.234

7.  Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite.

Authors:  R B Nadelman; J Nowakowski; D Fish; R C Falco; K Freeman; D McKenna; P Welch; R Marcus; M E Agüero-Rosenfeld; D T Dennis; G P Wormser
Journal:  N Engl J Med       Date:  2001-07-12       Impact factor: 91.245

8.  Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial.

Authors:  L B Krupp; L G Hyman; R Grimson; P K Coyle; P Melville; S Ahnn; R Dattwyler; B Chandler
Journal:  Neurology       Date:  2003-06-24       Impact factor: 9.910

9.  An analysis of spirochete load, strain, and pathology in a model of tick-transmitted Lyme borreliosis.

Authors:  N S Zeidner; B S Schneider; M C Dolan; J Piesman
Journal:  Vector Borne Zoonotic Dis       Date:  2001       Impact factor: 2.133

Review 10.  Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease.

Authors:  Mark S Klempner
Journal:  Vector Borne Zoonotic Dis       Date:  2002       Impact factor: 2.133
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  10 in total

1.  Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and Ixodes scapularis ticks using a doxycycline hyclate-laden bait.

Authors:  Marc C Dolan; Terry L Schulze; Robert A Jordan; Gabrielle Dietrich; Christopher J Schulze; Andrias Hojgaard; Amy J Ullmann; Cherilyn Sackal; Nordin S Zeidner; Joseph Piesman
Journal:  Am J Trop Med Hyg       Date:  2011-12       Impact factor: 2.345

Review 2.  Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease.

Authors:  Daniel J Cameron; Lorraine B Johnson; Elizabeth L Maloney
Journal:  Expert Rev Anti Infect Ther       Date:  2014-07-30       Impact factor: 5.091

3.  Ineffectiveness of tigecycline against persistent Borrelia burgdorferi.

Authors:  Stephen W Barthold; Emir Hodzic; Denise M Imai; Sunlian Feng; Xiaohua Yang; Benjamin J Luft
Journal:  Antimicrob Agents Chemother       Date:  2009-12-07       Impact factor: 5.191

4.  Evaluation of Doxycycline-Laden Oral Bait and Topical Fipronil Delivered in a Single Bait Box to Control Ixodes scapularis (Acari: Ixodidae) and Reduce Borrelia burgdorferi and Anaplasma phagocytophilum Infection in Small Mammal Reservoirs and Host-Seeking Ticks.

Authors:  Marc C Dolan; Terry L Schulze; Robert A Jordan; Christopher J Schulze; Amy J Ullmann; Andrias Hojgaard; Martin A Williams; Joseph Piesman
Journal:  J Med Entomol       Date:  2017-03-01       Impact factor: 2.278

5.  Transmission cycles of Borrelia burgdorferi and B. bissettii in relation to habitat type in northwestern California.

Authors:  Lars Eisen; Rebecca J Eisen; Jeomhee Mun; Daniel J Salkeld; Robert S Lane
Journal:  J Vector Ecol       Date:  2009-06       Impact factor: 1.671

6.  Efficacy of an experimental azithromycin cream for prophylaxis of tick-transmitted lyme disease spirochete infection in a murine model.

Authors:  Joseph Piesman; Andrias Hojgaard; Amy J Ullmann; Marc C Dolan
Journal:  Antimicrob Agents Chemother       Date:  2013-10-28       Impact factor: 5.191

7.  Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model.

Authors:  Jens Knauer; Inke Krupka; Christiane Fueldner; Joerg Lehmann; Reinhard K Straubinger
Journal:  J Antimicrob Chemother       Date:  2011-09-15       Impact factor: 5.790

8.  Evaluation of apoptosis imaging biomarkers in a genetic model of cell death.

Authors:  Vessela Vassileva; Stephen M Stribbling; Chris Barnes; Laurence Carroll; Marta Braga; Joel Abrahams; Kathrin Heinzmann; Caroline Haegeman; Marion MacFarlane; Kathryn L Simpson; Caroline Dive; Jamie Honeychurch; Timothy M Illidge; Eric O Aboagye
Journal:  EJNMMI Res       Date:  2019-02-19       Impact factor: 3.138

9.  Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo.

Authors:  Aref Shahini; Nika Rajabian; Debanik Choudhury; Shahryar Shahini; Kalyan Vydiam; Thy Nguyen; Joseph Kulczyk; Tyler Santarelli; Izuagie Ikhapoh; Yali Zhang; Jianmin Wang; Song Liu; Aimee Stablewski; Ramkumar Thiyagarajan; Kenneth Seldeen; Bruce R Troen; Jennifer Peirick; Pedro Lei; Stelios T Andreadis
Journal:  Sci Adv       Date:  2021-09-03       Impact factor: 14.136

10.  In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.

Authors:  David F Bruhn; Michael S Scherman; Jiuyu Liu; Dimitri Scherbakov; Bernd Meibohm; Erik C Böttger; Anne J Lenaerts; Richard E Lee
Journal:  Sci Rep       Date:  2015-09-14       Impact factor: 4.379
  10 in total

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