Literature DB >> 15215127

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide.

Chang-Jer Wu1, Jia-Tsrong Jan, Chi-Min Chen, Hsing-Pang Hsieh, Der-Ren Hwang, Hwan-Wun Liu, Chiu-Yi Liu, Hui-Wen Huang, Su-Chin Chen, Cheng-Fong Hong, Ren-Kuo Lin, Yu-Sheng Chao, John T A Hsu.   

Abstract

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

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Year:  2004        PMID： 15215127      PMCID： PMC434198          DOI： 10.1128/AAC.48.7.2693-2696.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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